Pituitary tumors are rare in childhood and adolescence, with a reported prevalence of up to 1 per million children. Only 2-6% of surgically treated pituitary tumors occur in children, with some variation attributed to a lack of consensus for a pediatric age range and whether age at surgery or age at onset of symptoms was used. Although pituitary tumors in children are almost never malignant and...

OBJECTIVE To determine whether pituitary adenomas can be diagnosed by identifying protein biomarkers in the serum. METHODS We compared serum proteins from 65 pituitary adenoma patients and 90 healthy donors using proteomic fingerprint technology combining magnetic beads with matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). RESULTS A total of 42 M/...

The authors report two cases of coexisting Rathke cleft cyst (RCC) and pituitary macroadenoma. Both patients presented at the university hospital with pituitary apoplexy symptoms of sudden-onset headache while undergoing treatment with Coumadin (warfarin). Magnetic resonance imaging was consistent with a pituitary adenoma in one case and RCC in the other. Intraoperative findings and pathologica...

• Explain how inappropriate (normal or increased) thyrotropin (TSH) secretion in the presence of hyperthyroidism can be a clue to a thyrotropin adenoma of the pituitary. • Describe the clinical and endocrinological features of thyrotroph pituitary adenoma and how to distinguish it from other states of inappropriate TSH secretion. • Define the roles of pituitary surgery, radiotherapy, and drug t...

INTRODUCTION The co-existence of pituitary adenoma and meningioma is extremely rare. It is even rarer in patients with no previous known risk factors for either tumour. Here, we present a case of synchronous non-functioning pituitary adenoma with suprasellar and olfactory groove meningiomas in a patient without previous irradiation. METHODS The tumours were diagnosed on MRI in the 65-year-old...

Haemorrhage in pituitary adenoma is an unusual cause of recurrent oculomotor palsy. Three episodes of right oculomotor palsy are reported from a patient having haemorrhage in pituitary adenoma. Early operation and decompression of haemorrhagic pituitary adenoma should be performed so that vision may be preserved and recovery of oculomotor palsy be assured.

Background: Pituitary adenoma is infrequent during pregnancy. As surgery for pituitary adenoma is hazardous, further complicated by physiological changes brought by pregnancy. Mostly such cases were managed with medical therapy. As surgical adenoma decompression during pregnancy represent a therapeutic challenge for decompression without producing any further stress to pregnant women and terato...

Background and Aim: Over the past 2 decades, endoscopy has become an integral part of the surgical repertoire for pituitary procedures and over the past several decades, the endoscopic endonasal trans sphenoidal approach (EETA) has gradually become an accepted option for pituitary tumors with intra-,supra-,and para-sellar location and extension, because of its minimal invasiveness and high effi...

Magmas is a nuclear gene that encodes for the mitochondrial import inner membrane translocase subunit Tim16. Magmas is overexpressed in the majority of human pituitary adenomas and in a mouse ACTH-secreting pituitary adenoma cell line. Here we report that Magmas is highly expressed in two out of four rat pituitary adenoma cell lines and its expression levels inversely correlate to the extent of...