Introduction Lupus nephritis (LN) is one of the main clinical presentations determining the course and outcome of systemic lupus erythematosus (SLE) in children. It occurs in 40–80% of pediatric patients at presentation and can be even higher during the later stages of the disease. The severity of the disease varies from mild glomerulonephritis to severe manifestations leading to end-stage rena...

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease that affects both adults and children, but with different degrees of severity. Indeed, pediatric (pSLE) more serious than the management heavier significant comorbidity. The clinical manifestations are polymorphic. skin one target organs most diversely affected by disease. Indeed cutaneous frequent, they almost cons...

Pediatric-onset inflammatory myositis (IM) and systemic lupus erythematosus (SLE) are rare inflammatory diseases. Both result from the complex interaction of genetic and environmental factors. An increasing number of Mendelian conditions predisposing to the development of SLE have been recently identified. These include monogenic conditions, referred to as the type I interferonopathies, associa...

To the Editor: We read with interest the recent article by Kyttaris and colleagues (1), in which they reported their finding that lupus-prone MRL/lpr mice had increased levels of NF-ATc1 (also known as NF-AT2) in the cytoplasmic and nuclear fractions of freshly isolated lymphocytes, as compared with control lymphocytes from MRL/MpJ mice. They reported no increase in the expression of NF-ATc2 (a...

Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and i...