During a 24-month period (May 1981 to May 1983), 47 pediatric patients (ranging in age from 7 months to 18 years) underwent orthotopic liver transplantation using cyclosporine and prednisone. Major indications were biliary atresia/hypoplasia, and metabolic liver disease. Thirty-two of 138 patients evaluated for the procedure died prior to transplantation. Thirty patients are alive from 6 to 29 ...

OBJECTIVE s To review issues associated with neurocognitive outcome in survivors of pediatric cancer. Recommendations are made for future research directions. METHODS A large body of literature pertaining to neurocognitive outcome in cancer survivors was reviewed. Brain development and methodological issues that provide challenges to conducting meaningful research in cancer outcomes also are ...

Advances in multimodality therapy have led to childhood cancer cure rates over 80%. However, surgery, chemotherapy, and radiotherapy may lead debilitating or even fatal long-term effects among survivors beyond those inflicted by the primary disease process. It is critical understand, mitigate, prevent these late of improve quality life survivors. This review summarizes various acknowledges Pedi...

Pediatric, adolescent, and young adult (PAYA) cancer survivors suffer from multiple domains of adverse psychosocial behavioral outcomes during after their treatment. This study conducted a systematic review metaanalysis psychosocial, behavioral, supportive interventions for PAYA survivors. We searched 11 electronic databases, 4 professional websites, manual search reference lists in existing re...

Scholars underline the pivotal role of tobacco cigarette smoking in carcinogenesis process for blood tumors. A controversial debate is represented by the diffusion of tobacco use in young cancer survivors that had a previous diagnosis of blood tumor during the childhood. Compared with their peers, scientific evidence highlights that pediatric survivors have more difficult to give-up cigarette s...

There are no universally approved re-vaccination guidelines for non-transplant pediatric cancer survivors. We hypothesized that by utilizing a response-based re-vaccination schedule, we could tailor vaccine schedules in off-treatment cancer survivors. Pre-vaccination antibody levels were obtained in 7 patients at an average of 20 days after the end of treatment date. In those without protective...

OBJECTIVE To assess social functioning and facial expression recognition skill in survivors of pediatric brain tumors (BT) as compared to children with juvenile rheumatoid arthritis (JRA). METHODS The social functioning of 51 survivors of BT and 31 children with JRA was assessed using a facial expression recognition task, questionnaire ratings of social functioning, and an IQ screener. RESU...

Background Pediatric cancer survivors after anthracycline therapy are at risk for left ventricular systolic dysfunction. Strain may be a more sensitive marker than left ventricular ejection fraction (LVEF). Feature tracking (FT) is a promising technique for strain measurement on cardiovascular magnetic resonance (CMR) images, but has limited validation vs. the gold standard of harmonic phase (H...

Purpose Pediatric cancer survivors often experience late effects secondary to cancer therapy, but their choices for symptom management is largely unknown. Many of these late effects can be treated by lifestyle changes such as diet, exercise, and conventional supplements. Although the use of lifestyle therapies appears common in children and adolescents, including pediatric cancer survivors, the...

Background Community acquired pneumonia (CAP) is a major infectious cause of mortality in preschool children especially in developing countries. Red Cell Distribution Width (RDW) has been associated with poor outcomes of CAP. We aimed to determine whether admission stress hyperglycemia and RDW can predict mortality in preschool children with CAP for early identification of patients at risk of ...