1 Chernoff Bounds 1.1 Bayesian Hypothesis Test A test using log-likelihood ratio statistic has the form, T (Y ) = logL(Y ) T τ. (1) Bound-1: The probability of error Pe is bounded as, Pe ≤ (π0 + π1e )eμT,0(s0)−s0τ , (2) where μT,0(s) = logE0[e ], and μ ′ T,0(s0) = τ . Bound-2: ∀ s ∈ [0, 1], Pe ≤ max(π0, π1e )eμT,0(s)−sτ . (3) Derivation of the above bound: Consider, Pe = π0P0(Γ1) + π1P1(Γ0), = ...

AIM Preliminary evidence suggests that inflammation plays a role in the development and prognosis of pulmonary embolism (PE). We used the neutrophil/lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with PE. MATERIALS AND METHODS A total of 266 patients who were diagnosed with PE and a control group of 124 age- and sex-matched healthy subjects were ...

PURPOSE To identify the frequency of polymorphism in the IL-10 gene, rs1800896 (-1082 A/G), in women with preeclampsia (PE) and in women in a control group and to associate the presence of this polymorphism with protection against the development of PE. METHODS This was a case-control study conducted on 54 women with PE, classified according to the criteria of the National High Blood Pressure...

BACKGROUND Acute massive pulmonary embolism (PE) carries an exceptionally high mortality rate. We explored how often adjunctive therapies, particularly thrombolysis and inferior vena caval (IVC) filter placement, were performed and how these therapies affected the clinical outcome of patients with massive PE. METHODS AND RESULTS Among 2392 patients with acute PE and known systolic arterial bl...

Podocyte injury has been suggested to induce phenotypic alteration of glomerular podocytes and accelerate the detachment of podocytes from the glomeruli resulting in podocyturia. However, it is not clear whether podocyte phenotypic alteration occurs in the urine of women with preeclampsia (PE). Seventy-seven and 116 pelleted urine samples from 38 and 18 women at various stages of normal and PE ...

The effect of nifedipine on fetal-placental blood flow at 22-24 weeks in patients with pregnancy-induced hypertension (PIH) was evaluated. Twenty patients with PIH were submitted to the Doppler evaluation of fetal-placental perfusion at 22-24 weeks. The systo-diastolic (SID) ratio and the pulsatility index (PI) of uterine, umbilical and middle cerebral arteries and systemic blood pressure were ...

We have read with interest the paper by Baptista et al., in which the authors propose that contrast-enhanced multidetector computed tomography (MDCT) may help assess prognosis in patients with intermediateto high-risk pulmonary embolism (PE).1 MDCT has traditionally been used for diagnostic purposes, but its potential role as a prognosticator in PE has been the subject of several studies in the...

OBJECTIVE The objective of our study was to estimate the mortality benefit-to-risk ratio of pulmonary CT angiography (CTA) by setting (ambulatory [emergency department or outpatient] or inpatient), age, and sex. MATERIALS AND METHODS A retrospective evaluation of 1424 consecutive pulmonary CTA examinations was performed and the following information was recorded: examination setting, patient ...

The effects of eritadenine, a constituent of the Lentinus edodes mushroom, and ethanolamine, the base constituent of phosphatidylethanolamine (PE), on fatty acid desaturase activities and lipid profiles were investigated comparatively in rats. Rats were fed a control diet or a diet supplemented with either eritadenine (0.05 g/kg) or ethanolamine (8 g/kg) for 14 d. Eritadenine and ethanolamine h...

OBJECTIVE Several conditions are associated with increased preeclampsia (PE) risk. Whether altered maternal angiogenic factor levels contribute to risk in these conditions is unknown. Our objective was to compare angiogenic biomarker patterns in high-risk pregnancies and low-risk controls. STUDY DESIGN We conducted a planned secondary analysis of a 2-center observational study of angiogenic b...