It has long been known that N-acylethanolamine phospholipids [N-acylphosphatidylethanolamine (N-acyl PE)] and N-acylethanolamines (NAEs) accumulate in mammalian tissues undergoing degenerative membrane changes associated with necrosis. Here we studied the effects of stress factors (UVB irradiation and serum deprivation) on the endogenous levels of N-acyl PE and NAE in mouse epidermal JB6 P(+) c...

OBJECTIVE To evaluate a soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio cut-off of 38 for the prediction of pre-eclampsia (PE) in routine assessment in singleton pregnancies at 30-37 weeks' gestation. METHODS This was a prospective observational study in women attending a third-trimester ultrasound scan at 30-37 weeks as part of routine pregnancy care. Seru...

background: premature ejaculation (pe) is the most common sexual disorder in men and studies reported prevalence up to 30% (1, 2). pe is not a life-threatening medical condition but it influences the quality of life (qol). objectives the aim of this study was to compare the efficiency, and safety of alpha blocker drugs in the treatment of patients with premature ejaculation (pe). additionally w...

The incorporation of several anti-rodent masterbatches into polyethylene (PE) granules used for gas pipes and the effects of the masterbatches on the physical properties of the pipes were studied. Four commercial anti-rodent masterbatches from different international companies including, Clariant, Alchemix, PolyOne, and Newgen were used in this research. Each of the masterbatch was primarily dr...

BACKGROUND The combination of cisplatin and etoposide (PE) has been a standard treatment for patients with poor-prognosis small cell lung cancer (SCLC). This non-inferiority design trial aimed to determine whether the combination of gemcitabine and carboplatin (GC) results in similar survival but is less toxic with better quality of life. METHODS Previously untreated patients with SCLC with e...

We investigated the biological activity of four new synthetic analogs of lipid A, termed PE-1, PE-2, PE-3, and PE-4. All compounds contain an alpha-oxyethyl-linked (-O-CH2-CH2-) phosphoryl group in position 1 of the reducing glucosaminyl residue (GlcN I) of lipid A. PE-1 is a hexaacylated analog of Escherichia coli lipid A (compound 506). PE-2 differs from PE-1 in carrying two myristic acid res...

Abnormal lipid metabolisms are closely associated with cancers. In this study, mass spectrometry was employed to in situ investigate the associations of membrane lipid phenotypes of six human lung cancer cell lines (i.e., A549, H1650, H1975 from adenocarcinoma, H157 and H1703 from squamous cell carcinomas, and H460 from a large cell carcinoma) with cancer cell types and finally total 230 lipids...

In 1971, Szucs et al1 reported a series of 50 nonconsecutive angiographically proven cases of pulmonary embolism (PE), all of which with Pao2 80 mm Hg, ie, “hypoxemia.” They concluded that normoxemia effectively excludes the diagnosis of PE. In succeeding issues of CHEST, there quickly followed a dozen or more well-documented exceptions to this rule. This was one of the first of many such “fail...