Organochlorine compounds are released from body fat into the bloodstream during weight loss. Because these compounds may impair thyroid status, which is implicated in the control of resting metabolic rate (RMR), the aim of this study was to determine if the augmentation in plasma organochlorine concentrations might be associated with the decrease in serum T(3) concentration and RMR observed in ...

Previous studies from our laboratory have shown that ethylene, vinyl fluoride monomer (VFM), vinyl chloride monomer (VCM), and vinyl bromide monomer (VBM) are all acutely hepatotoxic in rats pretreated with polychlorinated biphenyl (PCB). The time course of hepatic injury development after exposure and several parameters, environmental and chemical, affecting this toxicity were evaluated in the...

In the original version of this Article, Affiliation 2 was omitted for Qinghua Zhang. In addition, there were typographical errors. In the Results section under subheading 'Chromatographic separation' " The peak resolution factors (R s) of these chiral compounds were generally high than 1 except for PCB-174 and-83 " now reads: " The peak resolution factors (R s) of these chiral compounds were g...

BACKGROUND Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window. OBJECTIVES Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant. METHODS Seventy-nine women planning pregnancies we...

Dioxins and dioxin-like compounds encompass a group of structurally related heterocyclic compounds that bind to and activate the aryl hydrocarbon receptor (AhR). The prototypical dioxin is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic industrial byproduct that incites numerous adverse physiological effects. Global commercial production of the structurally similar polychlorinated bi...

Selected PCB congeners (PCB 52, 77, and 153) singly and in mixtures were spiked and aged in soil microcosms and subsequently planted with switchgrass (Panicum virgatum) or poplar (Populus deltoids x nigra DN34). The planted reactors showed significantly greater reductions in PCB parent compounds when compared to unplanted systems after 32 weeks, both in single congener exposures and when all th...

The levels of eight PCB congeners (IUPAC 8, 20, 28, 52, 101, 118, 138 and 180) and 13 organochlorine pesticides (a-HCH, b-HCH, Lindane, Heptachlor, Heptachlor epoxide, Aldrin, Dieldrin, Endrin, 2,4'-DDT, 2,4'-DDD, 4,4'-DDT 4,4'-DDD and 4,4'-DDE) were measured in eggs of Mediterranean gulls (Larus melanocephalus) (Lm), avocets (Recurvirostra avosetta) (Ra) and common terns (Sterna hirundo) (Sh) ...

Title of Document: EFFECTS OF PCB EXPOSURE ON HEPATIC GENE EXPRESSION AND ENZYME ACTIVITY IN AVIAN SPECIES Meredith E. Bohannon, Doctor of Philosophy, 2014 Directed By: Professor M.A. Ottinger, Department of Animal and Avian Sciences Polychlorinated biphenyls (PCBs) are a class of anthropogenic chemical compounds used by industry from the 1940s until the 1970s. Two General Electric plants at Fo...

OBJECTIVES To estimate the internal PCB level in Swedish workers specialised in PCB abatement in buildings and to measure possible effects of PCB on thyroid function and aspects of the immune system. METHODS Thirty six of 40 eligible workers (90%) removing old elastic sealants containing PCB and 33 control construction workers provided blood samples for determination of 19 PCB congeners and s...

BACKGROUND Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins, and poly-chlorinated dibenzofurans adversely affect the health of humans and various animals. Such effects might be partially exerted through the thyroid hormone (TH) system. We previously reported that one of the hydroxylated PCB congeners suppresses TH receptor (TR)-mediated transcription by dissociating TR from t...