Many Michigan farm children are viewed as having suffered a deterioration in health coincident with contamination of dairy cattle by PBBs. Among Wisconsin dairy farm children such a deterioration was a rare event. There is a suggestion that Michigan farm children who had multiple symptoms during the 1973-76 period are getting better. A discrete syndrome of ill health has not been identified amo...

1. Ashby J. a2p-Globulin nephropathy in white ravens [letter]. Environ Health Perspect 104 (12):1264 (1996). 2. Baserga R The cell cycle: myths and realities. Cancer Res 50:6769-6771 (1990). 3. Barrett JC, Huff JE. Cellular and molecular mechanisms of chemically induced renal carcinogenesis. In: Nephrotoxicity. Mechanisms, early diagnosis, & therapeutic management (Bach PH, Gregg NJ, Wiks MF, D...

The intactness of the immune system in cattle exposed to polybrominated biphenyls (PBBs) has been investigated by using several immunoassays. Eighty-seven animals have been studied, 35 control animals (not exposed to PBBs) and 52 animals exposed to PBBs (0.02-30 ppm/g fat equivalent). The immunoassays included a complete blood count, identification of peripheral blood T and B lymphocyte subpopu...

In this issue of Neuron, Maruyama et al. (2013) demonstrate the binding of a new class of selective tau ligands, termed PBBs, to tau deposits in transgenic mice and in human subjects with normal cognition, Alzheimer's disease, or a corticobasal syndrome.

BACKGROUND Limited epidemiologic studies have examined the association between maternal low-level lead exposure [blood lead (PbB) < 10 µg/dL] and fetal growth. OBJECTIVE We examined whether maternal low-level lead exposure is associated with decreased fetal growth. METHODS We linked New York State Heavy Metals Registry records of women who had PbB measurements with birth certificates to ide...

We report on the comparative bioaccumulation, biotransformation and/or biomagnification from East Greenland ringed seal (Pusa hispida) blubber to polar bear (Ursus maritimus) tissues (adipose, liver and brain) of various classes and congeners of persistent chlorinated and brominated contaminants and metabolic by-products: polychlorinated biphenyls (PCBs), chlordanes (CHLs), hydroxyl (OH-) and m...

Protected areas are a leading conservation tool for preserving biodiversity. However, the restrictions on human uses often engender resistance of local communities to idea living in protected environment. This paper describes preparation Biodiversity Investment Opportunities (BIO) maps seven case Central and South-Eastern Europe, using participatory methods. BIO have been further developed with...

OBJECTIVES To describe 6 h urinary lead excretion (6 h PbU) after 1 g intravenous ethylene diamine tetraacetic acid (EDTA) in organolead manufacturing workers with mixed exposure to organic and inorganic lead; to determine the predictors of lead excretion (PbU); and to determine the extent to which internal lead stores and ongoing external exposure govern blood concentrations of lead (PbB). M...

Accidental contamination of livestock feed in 1973 by polybrominated biphenyls (PBB) led to the destruction of over 30,000 animals in Michigan. Animal carcasses of mostly dairy cattle along with some beef cattle, hogs, sheep and rabbits destroyed under the Federal Food and Drug Administration guidelines were disposed on the land at an environmentally safe site in Kalkaska County, Michigan. The ...