background: in diagnostic radiology there are two reasons for measuring or estimating radiation doses to patients. firstly measurements provide a means for setting and checking standards of good practice as an aid to the optimization of patient protection. secondly estimates of the absorbed dose to tissue and organs in the patients. materials and methods: a total of 2382 patients were studied t...

background:  this study presents patient specific and organ dose estimation in computed tomography (ct) imaging of thorax directly from patient ct image using monte carlo simulation.  patient's ct image is considered as the patient specific phantom and the best representative of patient physical index in order to calculate specific organ dose. materials and methods: egsnrc /beamnrc monte c...

background: patient radiation doses from computed tomography (ct) are increasing due to the number of ct examinations performed every day. the aim of this study was assess and evaluate patient radiation doses for adult’s common ct examinations to derive local diagnostic guidance levels for common ct examinations. materials and methods: volume and weighted computed tomography dose index (ctdivol...

The aim of this study is to assess the radiation exposure patient and medical staff during interventional cardiology procedures. Realistic scenarios were developed using adult reference anthropomorphic phantoms adopted by International Commission on Radiological Protection ( ICRP 110 Male Female ), transport code Geant4 (version 10.3 ). calculated equivalent effective doses normalised simulated...

background: the most efficient application of ionizing radiation is serving medical purposes and using this radiation has caused people to learn that artificial sources of radiation exposure among these resources can be of highest exposure rate.   objective: the present study is aimed at initially establishing a baseline for local-reference dose level in mazandaran, iran in 12 projections of th...

Survival time-associated plant homeodomain (PHD) finger protein in Ovarian Cancer 1 (SPOC1, also known as PHF13) is known to modulate chromatin structure and is essential for testicular stem-cell differentiation. Here we show that SPOC1 is recruited to DNA double-strand breaks (DSBs) in an ATM-dependent manner. Moreover, SPOC1 localizes at endogenous repair foci, including OPT domains and accum...

We have investigated the nuclear import strategies of high-risk HPV18 L2 minor capsid protein. HPV18 L2 interacts with Kap alpha2 adapter, and Kap beta2 and Kap beta3 nuclear import receptors. Moreover, binding of RanGTP to either Kap beta2 or Kap beta3 inhibits their interaction with L2, suggesting that these Kap beta/L2 complexes are import competent. Mapping studies show that HPV18 L2 contai...

The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a dual-specificity phosphatase that dephosphorylates Cdk2 and inhibits cell cycle progression. The overexpression of KAP has been found in breast, prostate and renal cell carcinomas. However, the role of KAP in hepatocellular carcinoma (HCC) remains unclear. Therefore, the a...

Transport of macromolecules between the cell nucleus and cytoplasm occurs through the nuclear pores and is mediated by soluble carriers known as karyopherins (Kaps), transportins, importins, or exportins. We report that Kap 2B (transportin-2) forms complexes with the mRNA export factor TAP in the presence of RanGTP, as shown by coimmunoprecipitation from HeLa cells. The interaction strictly dep...

DNA NHEJ (non-homologous end-joining) is the major DNA DSB (double-strand break) repair pathway in mammalian cells. Although NHEJ-defective cell lines show marked DSB-repair defects, cells defective in ATM (ataxia telangiectasia mutated) repair most DSBs normally. Thus NHEJ functions independently of ATM signalling. However, approximately 15% of radiation-induced DSBs are repaired with slow kin...