Heterotopic ossification (HO) is the pathologic formation of bone separate from the normal skeleton. Although several models exist for studying HO, an understanding of the common in vitro properties of cells isolated from these models is lacking. We studied three separate animal models of HO including two models of trauma-induced HO and one model of genetic HO, and human HO specimens, to charac...

Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we demonstrate endothelial Yap/Taz is a novel regulator of intramembranous ossificat...

choanal polyps are a form of nasal polyps that grow toward the choana with a single stalk. septochoanal polyp is a rare entity that originates from the mucosa of the nasal septum with choanal extension. the most common site of its origin is mainly the superior aspect of the posterior portion of the nasal septum. however, metaplastic ossification is a rare event in nasal polyp and to the best of...

BACKGROUND AND PURPOSE Endochondral ossification of the otic capsule is a process that continues postnatally; hence, incomplete endochondral ossification is seen as pericochlear hypoattenuation on temporal bone CT scans of children. We determined the prevalence and extent of this entity in a large series and assessed its relation to age and underlying sensorineural hearing loss. MATERIALS AND...

aim : the aim of this study was to comprehensively analyze histopathologic parameters of whipple pancreaticoduodenectomy specimens at taleghani general hospital pathology department. background : the whipple procedure is performed for variety of tumors involving the head of the pancreas, ampulla of vater, common bile duct, or duodenum. patients and methods : records of all cases of whipple panc...

The ossification level of tarsal bones and the distal end of the tibia in human foetuses of both sexes from 4 to 9 month gestational age was estimated. Our results show that ossification of the cartilaginous model tarsal bones begins from 6 to 7 months of the gestational age with the appearance of a single ossification point in the ankle bone and two ossification points in the heel bone with th...

Of 20 children who underwent cochlear implantation for profound sensorineural hearing loss secondary to bacterial meningitis, 14 had round-window and cochlear ossification at surgery. Preoperative polytomography demonstrated ossification in 11 of these. The incidence of ossification was highest after meningitis secondary to pneumococcal pneumonia. In only one of four children with severe ossifi...

Clinical symptoms of stylohyoid chain ossification vary from ear pain to dysphagia. It is usually diagnosed coincidentally. Localized ossification of the chain is common, whereas diffuse ossification is rare. Herein, a case with bilateral diffuse stylohyoid chain ossification diagnosed with computed tomography, which was performed in order to evaluate the patient's temporomandibular joint pain,...

We evaluated the incidence of heterotopic ossification following total ankle replacement to determine whether the degree of ossification was associated with the clinical outcome. We evaluated 90 ankles in 81 consecutive patients who underwent total ankle replacement, and heterotopic ossification was assessed according to proportional involvement of the ankle joint. Correlation analysis was used...