The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

Pogostemon cablin (Blanco) Benth. (Patchouli) is an important traditional Chinese medicinal plant that has both essential oil value and a broad range of therapeutic effects. Here we report the first de novo assembled 1.15-Gb draft genome sequence for P. cablin from next-generation sequencing technology. Our assembly, with a misassembly rate of <4 bp per 100 kb, is ~73% of the predicted genome s...

Pogostemon cablin Benth. var ‘Sidikalang’ leaves are the main source of patchouli oil which is used in cosmetics and perfume industry because its better fixative nature provides foreign exchange around 60 % Indonesia’s essential export revenues largest supplier world with a contribution 90 %. But apparently, several studies found that also has pharmacological activity such as aromatherapy, anti...

This study aimed to evaluate the aromatic characteristic of patchouli essential oil (Pogostemon cablin Benth.) by near‐infrared spectroscopy combined with chemometric treatments. The used 84 samples collected from around Indonesia, namely in Konawe, Kolaka, Bogor, Garut, Aceh, Jambi, and Masamba. Several pretreatments were process spectral data, together application partial least squares. spect...

cablin (BLANCO) BENTH. (Family Labiatae), commonly known as “Guang-Huo-Xiang” or Cablin Patchouli. It is a Chinese Materia Medica traditionally used for the treatment of common cold, nausea and diarrhea. Patchouli oil, the volatile oil of P. cablin, has been widely used in the cosmetic and oral hygiene industries to scent perfumes, flavor toothpaste, etc. Modern researches have repeatedly demon...

Cacao is a plant that belongs to the Malvaceae family. The n-hexane extract of cocoa pod husks (Theobroma cacao L) and its fraction was determined for cytotoxic activity by Brine Shrimp Lethality Test (BSLT) method which showed very strong activity. Isolation chemical components from Theobroma L. 7.4 (TCH 7.4) TCH 9.1 subfraction obtained with LC50 value 20.39 ppm 5.52 ppm, respectively. compou...

Valeriana wallichii (Family Valerianaceae), popularly named as Indian valerian, exists as three chemotypes. Aim of the study was to evaluate the effect of V. wallichii chemotype (patchouli alcohol) extract (DCME) and essential oil (VPAEO) on experimental models of nociception and to elucidate its possible mechanism of action. Analgesic effect was evaluated using acetic acid induced writhing and...

The yeast Saccharomyces cerevisiae was chosen as a microbial host for heterologous biosynthesis of three different plant sesquiterpenes, namely valencene, cubebol, and patchoulol. The volatility and low solubility of the sesquiterpenes were major practical problems for quantification of the excreted sesquiterpenes. In situ separation of sesquiterpenes in a two-phase fermentation using dodecane ...