Novel means of fabricating polymeric microfluidic devices are presented. An SU-8 master is applied in two-stage embossing, followed by vaporized organic solvent bonding. The primary master is created by standard photolithography; the inexpensive SU-8 primary master is used in a two-stage process to generate microfeatures in hard polymers. A vaporized solvent bonding technique that readily produ...

This paper proposes a new "twisted" 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circl...

In this study, geometrically modified microchannels fabricated using a stereolithography technique are employed to analyze micromixing of polymeric solutions. Experimental and numerical analyses were conducted evaluate the qualitative quantitative validity Newtonian fluid flow inside channels. An in-house image processing code was used dye concentration distributions resulting from complex tran...

Mixing within the microdomain is limited because convective mixing cannot be achieved since diffusion dominates as the main form of transport. Hence microassays can take on the order of 1 to 72 h, without the aid of a passive or active mixer to shorten the time of transport of a target molecule to a probe (Lai et al., 2004). Liu et al. (2002, 2003) developed a low cost cavitation microstreaming...

In this paper, a sequence of passive micromixers with spiral patterns on the side wall cylindrical chambers are designed, optimized, prepared and tested. The simulation studies show that vortex magnitude continuity in mixing chamber most important factors to determine performance, while inlet position structural parameters secondary influences their performance. According above principles, perf...

A novel parallel laminar micromixer with a two-dimensional staggered Dean Vortex micromixer is optimized and fabricated in our study. Dean vortices induced by centrifugal forces in curved rectangular channels cause fluids to produce secondary flows. The split-and-recombination (SAR) structures of the flow channels and the impinging effects result in the reduction of the diffusion distance of tw...

We demonstrate an improved femtosecond laser irradiation followed by chemical etching process to create complex three-dimensional (3D) microchannels with arbitrary length and uniform diameter inside fused silica. A segmented chemical etching method of introducing extra access ports and a secondary power compensation is presented, which enables the fabrication of uniform 3D helical microchannels...

Passive micromixing can efficiently mix laminar flows through molecular and convective diffusion. Microstructures are expected to be efficient, easily integrated into micromixers, suitable for micromixers over a wide range of Re. This paper presents the enhancement effects multiscale lateral microstructures on flow field characteristics mixing efficiency numerical simulations at Re = 0.01–50. I...