Sevil Hakimi, Sakineh Hajebrahimi, Parvin Bastani, Elham Aminian, Samieh Ghana, Marzieh Mohammadi. Msm, PhD. Assistant Professor, Tabriz University of Medical Science, Tabriz, Iran; MD. Professor, Tabriz University of Medical Science, Tabriz, Iran; Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; MSm Student. Tabriz University of Medical Science,...

Raheleh Janani, Abdollah Jannatdoost, Alehe Seyedrasuli, Leila Valizadeh, Parvin Sarbakhsh. Member of educational board of nursing and midwifery faculty of Tabriz University of medical sciences, Iran; Department of medical surgical, nursing and midwifery faculty, Tabriz University of medical sciences, Iran; MD neonatal nursing of Alzahra hospital and head of research of Alzahra research committ...

Introduction Extracellular signaling is commonly mediated through mechanisms that rely on protein-protein interactions and protein phosphorylation. The dynamics of protein-protein interactions are often dependent on the activation of a particular signal transduction pathway. Even a single protein can affect various cellular functions by interacting with different partners in response to extrace...

The heterotrimeric protein complex containing the integrin linked kinase (ILK), parvin, and PINCH proteins, termed the IPP complex, is an essential component of focal adhesions, where it interacts with many proteins to mediate signaling from integrin adhesion receptors. Here we conduct a biochemical and structural analysis of the minimal IPP complex, comprising full-length human ILK, the LIM1 d...

The ILK, PINCH, Parvin (IPP) complex regulates adhesion and migration via binding of ILK to β1 integrin and α-parvin thus linking focal adhesions to actin cytoskeleton. ILK also binds the adaptor protein PINCH which connects signaling proteins including Rsu1 to the complex. A recent study of Rsu1 and PINCH1 in non-transformed MCF10A human mammary epithelial cells revealed that the siRNA-mediate...

An orchestrated interplay of adaptor and signaling proteins at mechano-sensitive sites is essential to maintain cardiac contractility and when defective leads to heart failure. We recently showed that Integrin-linked Kinase (ILK), ß-Parvin and PINCH form the IPP-complex to grant tuned Protein Kinase B (PKB) signaling in the heart. Loss of one of the IPP-complex components results in destabiliza...

The integrin-linked kinase (ILK), pinch and parvin ternary complex connects the cytoplasmic tails of beta1 integrins to the actin cytoskeleton. We recently showed that constitutive expression of ILK and alpha parvin in both the ureteric bud and the metanephric mesenchyme of the kidney is required for kidney development. In this study, we define the selective role of ILK in the ureteric bud of t...

Cells must divide strictly along a plane to form an epithelial layer parallel to the basal lamina. The axis of cell division is primarily governed by the orientation of the mitotic spindle and spindle misorientation pathways have been implicated in cancer initiation. While β1-Integrin and the Dynein/Dynactin complex are known to be involved, the pathways linking these complexes in positioning m...

Effect of Blood Contamination on Delta 450 Bilirubin Measurement: An in Vitro Comparison of Two Corrective Methods, Kirk Foster, Jennifer Moore, Kelly Hankins, Curtis A. Parvin, and Ann M. Gronowski ( Department of Pathology and Immunology, Division of Laboratory Medicine, Washington University School of Medicine, St. Louis, MO; 2 Barnes-Jewish Hospital, St. Louis, MO * address correspondence t...