When human platelets in citrated plateletrich plasma (PRP) were incubated for up to 7 mm at 37#{176} C and pH 7.8 with EDTA, they progressively lost their ability to aggregate and, after separation from plasma, were found in progressively greater numbers in the upper phase of a two-phase dextranpolyethylene glycol system (i.e., had a higher partition coefficient). Partition values were also inc...

A helium-neon laser was used to measure the alcohol content of breath from six volunteers at regular intervals over up to four hours. The corresponding blood values were calculated with a blood : breath partition coefficient of 2100. When these values were compared with those obtained by direct measurement it was obvious that substantial variations occurred from one person to another in the der...

A new method was developed for determining directly the distribution of 133Xe between red cells and plasma in vitro without an air-fluid interface; the partitioning of 133Xe and 133-i-iodantipyrine between blood and myocardium was investigated in the dog in situ. The red cell-plasma partition coefficient for 133Xe (lambdacpX, unit: ml/ml) at 37 degrees C was 2.27 +/- 0.07 (mean +/- SD) for huma...

paracetamol is a sparingly soluble bitter tasting drug. it is widely used as an analgesic and antipyretic. complexation of drug with different cyclodextrins (?, ? and hp-?-cd) was attempted to improve solubility of paracetamol. during the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of paracetamol w...

BACKGROUND Blood-tissue partition coefficients indicate how a chemical will distribute throughout the body and are an important part of any pharmacokinetic study. They can be used to assess potential toxicological effects from exposure to chemicals and the efficacy of potential novel drugs designed to target certain organs or the central nervous system. In vivo measurement of blood-tissue parti...

A simple method for the direct determination of the air-loop volume in a RAD7 system as well as the radon partition coefficient was developed allowing for an accurate measurement of the radon activity in any type of water. The air-loop volume may be measured directly using an external radon source and an empty bottle with a precisely measured volume. The partition coefficient and activity of ra...