Background: To determine mean prothrombin time and activated partial thromboplastin time in patients of end stage renal disease having normal baseline coagulation parameters after hemodialysis. Methods: In this cross sectional study 84 patients ,16-70 years of age, with end stage renal disease were selected. Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were performed p...

Gastric dilatation and volvulus syndrome is associated with changes in haemostatic profiles. The aims of this study were to compare selected haemostatic and fibrinolytic parameters between healthy dogs and dogs with gastric dilatation and volvulus syndrome, estimate the incidence of disseminated intravascular coagulation (DIC), and determine the most sensitive test for detection of DIC in these...

Deficiencies of factor VIII (in haemophilia) and factor IX (in Christmas disease) prolong the partial thromboplastin time. If normal plasma is treated with alumina, the factor VIII remains but the factor IX is removed and can subsequently be recovered by elution of the alumina. If a long partial thromboplastin time is found on investigating a male patient whose history suggests a life-long blee...

A 2-month-old infant was admitted for irritability and hypomobility of the left lower limb. Ultrasound revealed a deep hematoma iliopsoas muscle coagulation tests showed increased activated partial thromboplastin time (aPTT).

Difficulties in evaluating the anticoagulant effect of heparin led to studies of the rate of disappearance of its effect on the whole body partial thromboplastin time, and of its simultaneously bioassayed plasma concentration. The slope of the anticoagulant's dose-effect curve varied with each subject's baseline coagulation status, which probably accounts for the wide range of clinically observ...

presented in a clearer and more comprehensive way; thus, enabling clinicians to understand the advantages and shortcomings of idarucizumab. Furthermore, as mentioned above, there is a need for an independent prospective randomized trial, which compares current guideline-recommended practices for reversal of dabigatran with idarucizumab in patients with life-threatening bleedings and those requi...

Eight of 1 1 children of a known Fletcher taming celite or kaolin were sensitive to factor-deficient individual were found to Fletcher factor deficiency, while one rehave normal activated partial thromboagent containing ellagic acid did not deplastin times, normal levels of factors VIII, tect this abnormality. The finding of an IX, Xl, and XII, and a mean Fletcher factor abnormal partial thromb...

While we read with great interest the recent report concerning the reversal of dabigatran-induced coagulopathy [1], we are concerned that methodological issues limit the validity of the authors’ conclusions. Firstly, it is unclear why a porcine model was utilized. Although there is clinical relevance for testing reversal agents in a trauma model, all agents were administered ex vivo. Furthermor...

‘ITHE partial thromboplastin time assay (PTT) as developed by Langdell et al. (1) has proved to be a very usef ul test for studying the coagulatioll mechanism silice it C 11 reveal tile al)SellCe of any factor except Factor VII and platelets. lnder rigorously cOlitrolled COll(litiOlIS, the reproducibility of tile test is satisfactory. However, any change ill tile surface of the svl’inge, test t...