Background:Hepatotoxicity is a well-known adverse effect of methotrexate therapy.
 Objective: To assess liver functions such as ALT and AST in patients with rheumatoid arthritis psoriatic receiving compare the those cured by using methotrexate.
 Patients Methods: This observational, cross-sectional analysis involved 50 RA who satisfied EULAR-ACR-2010 standards for PSA cases fulfilled ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the virus that caused COVID-19 pandemic. Initial symptoms include fever, cough, and dyspnea. Symptoms nausea, vomiting, abdominal pain, GIT involvement also possible. outbreak has increased need for alternative medicine administration routes, particularly in public places. Buccal, sublingual, rectal are all considered transmuc...

Preterm delivery is a public health issue of major proportion. More than 12% of deliveries in the United States that occur at less than 37 weeks gestation preterm labor (PTL) represents the largest single reason for preterm birth (PTB). Attempts to prevent PTB have been unsuccessful. This paper of maintenance tocolytic therapy will examine the efficacy and safety of the drugs, both oral and sub...

Multiple sclerosis (MS) is a chronic autoimmune disease that usually affects young adults, causing progressive physical and cognitive disability. Since the 1990s, its treatment has been based on parenteral medications known collectively as immunomodulators. This drug class is considered safe and usually prevents 30% of MS relapses. Drugs in this class exert almost the same efficacy and require ...

BACKGROUND Previous studies have documented the increased cardiovascular risk associated with the use of some nonsteroidal anti-inflammatory drugs (NSAIDs). Despite this, many old NSAIDs are still prescribed worldwide. Most of the studies to date have been focused on specific oral drugs or limited by the number of cases examined. We studied the risk of new acute myocardial infarction (AMI) hosp...

There were 7276 e-mail requests sent to dentists in the United States and Canada requesting participation in a short web-based survey to update earlier information regarding the use of dental outpatient sedation. Participants were questioned regarding their use of dental outpatient sedation, including the frequency of use, type of sedation used, route ofadministration, medications used, physiol...

Objectives: The purpose of this study was to explore intravenous (IV) medication errors in a Chinese hospital. The specific objectives were to 1) explore and measure the frequency of IV medication errors by direct observation and identify clues to their causes in Chinese hospital inpatient wards and 2) identify the clinical importance of the errors and find the potential risks in the preparatio...

Opioids are a mainstay of treatment for pain worldwide. Pruritus, common side effect opioids, is patient dissatisfier that limits their use in many clinical settings. Both parenteral and neuraxial administration opioids frequently evoke pruritus. The ability to suppress while causing itch continues perplex clinicians researchers alike. Several mechanisms have been proposed explain how can give ...