نتایج جستجو برای: paraoxonase 1
تعداد نتایج: 2753342 فیلتر نتایج به سال:
BACKGROUND The HDL-associated enzyme paraoxonase protects LDLs from oxidative stress. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) appear to favorably influence the atherosclerotic process by different mechanisms. The present study examined the influence of simvastatin on paraoxonase expression and serum paraoxonase levels. METHODS AND RESULTS Simvastatin upregulated i...
Paraoxonase can hydrolyse organophosphate esters and paraxon is its most important substrate in laboratory studies. This enzyme circulates in blood with HDL. It seems that reduced paraoxonase activity in human may increase risk of coronary artery disease. Genetic variations in two autosomal genes may reduce its activity. These variations produce three phenotypes: A, AB and B. B phenotype ac...
The paraoxonase 1 codon 192 R allele has been previously reported to have a role in successful aging. The relationship between PON1 genotypes, enzymatic activity, and mass concentration was evaluated in a group of 229 participants from 22 to 104 years of age, focusing our attention on nonagenarian/centenarian participants. We found a genetic control for paraoxonase activity that is maintained t...
Background and Aims: Flavonoids as polyphenolic naturally occurring compounds have antioxidant activity. There is increasing evidence suggests that flavonoids may affect the activity of enzymes. Paraoxonase 1 is calcium - dependent enzyme that is present in high density lipoproteins. This enzyme has an important role in the prevention of low density lipoprotein oxidation. We investigated the ef...
The presence of a pro-oxidant state in patients with schizophrenia may account for the increased risk atherosclerosis and cardiovascular disease this group supports potential utility circulating biomarkers oxidative stress stratification management. We investigated issue by conducting systematic review meta-analysis association between concentrations paraoxonase-1, an antioxidant calcium-depend...
OBJECTIVE Newborn infants, particularly preterm infants, are at greater risk of oxidative stress because of an imbalance between high oxidant loads and immature antioxidant defenses. In several studies, the activities of serum paraoxonase (PON) and arylesterase (ARE) have been found to decline in patients under increased oxidative stress. We investigated the relationships between PON-1 and ARE ...
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