In this issue of the journal, Ardissino et al1 report that early volume expansion in children with hemolytic uremic syndrome associated with Shiga toxinproducing Escherichia coli (STECHUS) significantly improves clinical outcomes. The observation possesses significant clinical implications for the management of an illness that causes much morbidity and not infrequently, mortality.2 The data are...

It is very likely that in 10 years time, invasive prenatal diagnostic tests like amniocentesis and chorionic villus sampling (CVS) will join the club of forgotten obstetric procedures like vaginal breech delivery and rotational forceps delivery. In 1968, Henry Nadler1 and his team were the fi rst to report prenatal diagnosis of trisomy 21 from full karyotyping of cultured amniocytes obtained by...

W ith the worldwide growing prevalence of obesity and type 2 diabetes, cardiovascular disease (CVD), diabetic nephropathy, retinopathy, and neuropathy as principal complications of diabetes are expected to become a major public health challenge. Diabetes accounts for at least double the number of death rates compared with otherwise healthy individuals. Hyperglycemia represents the hallmark of d...