As far as we are aware, no distinction has been made between the biological activity of pantolactone (CL, y-dihydroxy-p, fl-dimethylbutyrolactone) and pantoic acid or its ion.1 In connection with studies on the antagonistic action of pantoyltaurine on salicylate inhibition of Escherichia coli 2 we have observed that pantoic acid, or, more properly, the pantoate ion, is more active than pantolac...

1. The B-vitamins in milk from baboons (Papio cynocephalus) at various stages of lactation were measured microbiologically. 2. Mature milk contained, on average (microgram/ml): thiamin 0.18 riboflavin 0.74, nicotinic acid 3.2, folate 0.03, vitamin B6 0.70 vitamin B12 0.002, pantothenic acid 2.63, biotin 0.0065. 3. Colostrum contained much less vitamin B6 and pantothenic acid than mature milk; o...

An important r81e for pantothenic acid in carbohydrate metabolism was suggested by studies in which pantothenic acid-deficient bacteria (1, 2) and liver (3) were observed to utilize pyruvate at rates much less than normal. The subsequent discovery of Lipmann and his colleagues that the coenzyme of acetylation (coenzyme A) (4) contained pantothenic acid (5) provided a stimulus for the reinvestig...

Although it appears most probable that coenzyme A is a phosphate derivative of pantothenic acid (2), little information is available as to the position or nature of the phosphate linkage in the molecule. It became of interest in this connection to examine the properties of simple phosphate derivatives of pantothenic acid, and for this purpose efforts were directed toward the preparation of the ...

It was found recently (1) that feeding a cholesterol-rich diet to pantothenic acid-deficient rats did not result in the fatty livers and high levels of cholesterol in liver and serum seen in comparable animals maintained on a normal diet. Decrease in food intake appeared not to account for this phenomenon, since the food intake of the deficient group on a body weight basis was higher than that ...