Sixty six patients undergoing elective valve surgery were randomized to receive rocuronium bromide 0.6 mg/Kg (Group R, n=22), pancuronium bromide 0.1 mg/Kg (Group P, n= 22) and vecuronium bromide 0.1 mg/Kg (Group V, n=22), Measurements of heart rate and arterial pressure (systolic, diastolic and mean) were noted at the following stages: 1) baseline when haemodynamics were stable for 2 minutes a...

Lymph flow into the thoracic duct of rats is reduced by 60% through immobilization with anesthesia. From this reduction, changes of the autonomic nervous activity by alpha-chloralose accounts for 20%. Pancuronium bromide blocking of the skeletal neuromuscular junction reduces lymph flow in the anesthetized rats by an additional 4%.

Pipecuronium bromide (Arduan) is a bisquaternary, steroid-type neuromuscular blocking agent in clinical use in Eastern Europe. Before its introduction into clinical practice in the USA, in the first phase of this study the neuromuscular potency of pipecuronium was determined under "balanced" and enflurance anaesthesia by the cumulative log dose-response method in 30 patients each. In the second...

The effect of TCE on the intraocular pressure was investigated in eight patients under thiopentone nitrous oxide/oxygen anaesthesia, using a muscle relaxant (pancuronium bromide). Pulmonary ventilation was controlled and the end-tidal carbon dioxide was maintained at 5 per cent. In every patient the intraocular pressure was observed to rise as TCE was administered and then to return to the init...

Two matched groups of patients with Hodgkin's disease undergoing a staging laparotomy received thiopentone, pancuronium bromide or suxamethonium 1.0 mg kg-1 (group 2) to facilitate tracheal intubation. There were no differences in the sites or degree of postoperative myalgia between the groups. It is concluded that efforts to reduce the frequency of suxamethonium muscle pains in patients having...