نتایج جستجو برای: pancreatic β cell

تعداد نتایج: 1877157  

2017
Alona Epshtein Eleonor Rachi Lina Sakhneny Shani Mizrachi Daria Baer Limor Landsman

OBJECTIVE The maintenance and expansion of β-cell mass rely on their proliferation, which reaches its peak in the neonatal stage. β-cell proliferation was found to rely on cells of the islet microenvironment. We hypothesized that pericytes, which are components of the islet vasculature, support neonatal β-cell proliferation. METHODS To test our hypothesis, we combined in vivo and in vitro app...

Journal: :Diabetes & metabolism journal 2016
Suk Chon Jean François Gautier

Type 2 diabetes mellitus (T2DM) is a multifactorial disease with a complex and progressive pathogenesis. The two primary mechanisms of T2DM pathogenesis are pancreatic β-cell dysfunction and insulin resistance. Pancreatic β-cell dysfunction is recognized to be a prerequisite for the development of T2DM. Therapeutic modalities that improve β-cell function are considered critical to T2DM manageme...

Journal: :Cancer research 2012
Aram F Hezel Vikram Deshpande Stephanie M Zimmerman Gianmarco Contino Brinda Alagesan Michael R O'Dell Lee B Rivera Jay Harper Scott Lonning Rolf A Brekken Nabeel Bardeesy

The TGF-β pathway is under active consideration as a cancer drug target based on its capacity to promote cancer cell invasion and to create a protumorigenic microenvironment. However, the clinical application of TGF-β inhibitors remains uncertain as genetic studies show a tumor suppressor function of TGF-β in pancreatic cancer and other epithelial malignancies. Here, we used genetically enginee...

Journal: :International journal of molecular sciences 2018
Kanaka Durga Devi Gorrepati Wei He Blaz Lupse Ting Yuan Kathrin Maedler Amin Ardestani

Loss of pancreatic β-cell function and/or mass is a central hallmark of all forms of diabetes but its molecular basis is incompletely understood. β-cell apoptosis contributes to the reduced β-cell mass in diabetes. Therefore, the identification of important signaling molecules that promote β-cell survival in diabetes could lead to a promising therapeutic intervention to block β-cell decline dur...

Journal: :Frontiers in Pharmacology 2016

Journal: :Journal of cellular and molecular medicine 2015
Qingqu Guo Wenjie Qin

The Wnt/β-catenin signalling pathway is activated in pancreatic cancer initiation and progression. Dickkopf-related protein 3 (DKK3) is a member of the human Dickkopf family and an antagonist of Wnt ligand activity. However, the function of DKK3 in this pathway in pancreatic cancer is rarely known. We examined the expression of DKK3 in six human pancreatic cancer cell lines, 75 pancreatic cance...

2012
Jae-Hyoung Cho

Corresponding author: Jae-Hyoung Cho Department of Endocrinology and Metabolism, Seoul St. Mary’s Hospital, The Catholic University of Korea School of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea E-mail: [email protected] It is well known that lipotoxicity can cause β-cells injury and/ or dysfunction as well as glucotoxicity [1-4]. If we could expect improvement of β-cell dy...

2012
Lulu Farhana Marcia I. Dawson Jayanta K. Das Farhan Murshed Zebin Xia Timothy J. Hadden James Hatfield Joseph A. Fontana

Pancreatic carcinoma has a dismal prognosis as it often presents as locally advanced or metastatic. We have found that exposure to adamantyl-substituted retinoid-related (ARR) compounds 3-Cl-AHPC and AHP3 resulted in growth inhibition and apoptosis induction in PANC-1, Capan-2, and MiaPaCa-2 pancreatic cancer cell lines. In addition, AHP3 and 3-Cl-AHPC inhibited growth and induced apoptosis in ...

Ali Gohari Ali Noorafshan, Atefeh Seghatoleslam, Fahimeh Zamani-Garmsiri Masoumeh Akmali

Background: Urtica dioica is known as an anti-hyperglycemic plant. Urtica dioica distillate (UD) is a traditional Iranian drink, locally known as “aragh gazaneh”. In spite of its widespread consumption in Iran, according to traditional Iranian medicine, there is no scientific report on the usefulness of UD for diabetic patients. This survey was designed to evaluate its protective effects for th...

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