OBJECTIVE Morbid obesity may be accompanied by diabetes and painful diabetic neuropathy, a poorly understood condition that is manifested by mechanical or thermal allodynia and hyperalgesia. Recent studies have highlighted the importance of T-type calcium channels (T-channels) in peripheral nociception; therefore, our goal was to examine the function of these channels in the pathophysiology and...

In the present study I investigated the effects of acupuncture treatment on the pain of diabetic neuropathy and parsesthesia as well as the duration of the morbidity and treatment results. The study examined subjective symptoms associated with diabetic neuropathy (like spontaneous pain and parsesthesia) in 38 patients (divided into a 20-patient group treated with acupuncture and an 18-patient d...

The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person's daily life, both physically and mentally. Despite huge advances in d...

Diabetes, a silent killer, is a leading cause of neuropathy. Around 50% of diabetic patients develop peripheral neuropathy in 25 years. Painful diabetic neuropathy manifests as burning, excruciating, stabbing or intractable type of pain or presents with tingling or numbness. The pathophysiology of this condition is due to primarily metabolic and vascular factors. There is increase in sorbitol a...

Preceding the joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetic Neuropathy in Toronto, Canada, 13-18 October 2009, expert panels were convened to provide updates on classification, definitions, diagnostic criteria, and treatments of diabetic peripheral neuropathies (D...

P neuropathy is one of the commonest long term complications of diabetes mellitus which has been reported to be prevalent in 22% of d iabe t i c cohor t . 1 Pa in fu l d iabe t i c neuropathy (PDN) occurs in 6% of the patients with diabetic peripheral neuropathy (DPN) and this is most distressing symptom which impairs quality of life.2 Patients seek advice to get relief but unfortunately treatm...

BACKGROUND Both basic and clinical research has demonstrated that antiepileptic drugs can be effective in alleviating neuropathic pain. It was hypothesized that oxcarbazepine might be effective in reducing the symptoms of painful diabetic neuropathy. AIMS To investigate the long-term efficacy and safety of oxcarbazepine in symptoms of painful diabetic neuropathy. MATERIALS AND METHODS This ...

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is involved in numerous physiological functions and plays a key role pain modulation including neuropathic pain. Diabetic neuropathy common complication of diabetes mellitus often accompanied by chronic Animal models offer relevant tools for studying the pathophysiological mechanisms pharmacological sensitivity diabetic identifying new ...

Methods: Data from three observational, retrospective studies are reported: carbohydrate metabolism, painful diabetic neuropathy (PDN), and hospital/ emergency department utilization. All studies utilized controlled microbursts of insulin via the Bionica Microdose system in patients with type 1 and type 2 diabetes. Indirect calorimetry was used to determine carbohydrate and metabolic rate measu...