We have previously demonstrated that the meningococcal antigen Ag473 in the presence of Freund's adjuvant can elicit protective immune responses in mouse challenge model. In this study, we evaluated the structural requirement for the immunological activity and the possible signaling pathway of recombinant Ag473 antigen produced in E. coli. We found that lipidated Ag473 (L-Ag473) possesses an in...

BACKGROUND Hepatitis E Virus (HEV) is the causative agent of enterically transmitted acute hepatitis and has high mortality rate of up to 30% among pregnant women. Therefore, development of a novel vaccine is a desirable goal. OBJECTIVES The aim of this study was to construct tPAsp-PADRE-truncated open reading frame 2 (ORF2) and truncated ORF2 DNA plasmid, which can assist future studies with...

Earlier work with the Parallel Document Retrieval Engine was oriented toward parallel machines such as the AP1000, characterised by many nodes, few disks, small memory per node (by current standards), single-user operation and high communication performance, relative to node computational power. Present generation parallel machines are much more like clusters of workstations (COWs). There are t...

Full-text scanning o ers signi cant advantages over other methods of document retrieval but is normally too slow for use on large collections. The Fujitsu AP1000 parallel distributed-memory machine has been used to reduce the time penalty for full-text scanning to acceptable interactive levels. The query language for the retrieval software (called PADRE) is described herein and di erences betwe...

CITAB – Centre for the Research and Technology of Agro-Environment and Biological Sciences, University of Trás-os-Montes e Alto Douro, Apartado 1013, 5001-801 Vila Real, Portugal Delegação Regional de Agricultura do Nordeste Transmontano, Avenida General Humberto Delgado, 5300-167 Bragança, Portugal c Instituto Nacional de Saúde Doutor Ricardo Jorge, I.P., Departamento de Alimentação e Nutrição...

Natural Resource Damage Assessment cases often call for compensation in nonmonetary or restoration equivalent terms. In this article, we present an approach that uses a conventional economic model, a travel cost random utility model of site choice, to determine compensatory restoration equivalents for hypothetical beach closures on the Gulf Coast of Texas. Our focus is on closures of beaches on...