The phoPR operon encodes a response regulator, PhoP, and a histidine kinase, PhoR, which activate or repress genes of the Bacillus subtilis Pho regulon in response to an extracellular phosphate deficiency. Induction of phoPR upon phosphate starvation required activity of both PhoP and PhoR, suggesting autoregulation of the operon, a suggestion that is supported here by PhoP footprinting on the ...

The synthesis of 4-(substituted benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one was achieved in two steps, In first step, pyrazine-2-carboxamide  dissolved in EtOH, 10% KOH solution with ClCH2COOH produced compound 2-(pyrazine-2-carboxamido) acetic acid (II) and in second step, compound (II) in (CH3CO)2O with aromatic aldehyde, and catalyst potassium ace...

Right heart catheterization is often required to monitor intra-cardiac pressures in a number of disease states. Ultrasound contrast agents can produce pressure modulated subharmonic emissions that may be used to estimate right ventricular (RV) pressures. A technique based on subharmonic acoustic emissions from ultrasound contrast agents to track RV pressures noninvasively has been developed and...

Two haemoglobins have been described that do not contain ac-chains: haemoglobin H (Rigas, Koler & Osgood, 1955, 1956; Gouttas, Fessas, Tsevremis & Xefteri, 1955) consists of four fA-polypeptide chains (Jones, Schroeder, Balog & Vinograd, 1959), and haemoglobin Bart's (Ager & Lehmann, 1958) consists of four yF-polypeptide chains (Hunt & Lehmann, 1959). These two abnormal haemoglobins are now ref...

Let K denote a field. Let d denote a nonnegative integer and consider a sequence p = (θi, θ ∗ i , i = 0...d;φj , φj , j = 1...d) consisting of scalars taken from K. We call p a parameter array whenever: (PA1) θi 6= θj, θ ∗ i 6= θ ∗ j if i 6= j, (0 ≤ i, j ≤ d); (PA2) φi 6= 0, φi 6= 0 (1 ≤ i ≤ d); (PA3) φi = φ1 ∑i−1 h=0 θh−θd−h θ0−θd + (θ i − θ ∗ 0)(θi−1 − θd) (1 ≤ i ≤ d); (PA4) φi = φ1 ∑i−1 h=0 ...

Let K denote a field. Let d denote a nonnegative integer and consider a sequence p = (θi, θ ∗ i , i = 0...d;φj , φj , j = 1...d) consisting of scalars taken from K. We call p a parameter array whenever: (PA1) θi 6= θj, θ ∗ i 6= θ ∗ j if i 6= j, (0 ≤ i, j ≤ d); (PA2) φi 6= 0, φi 6= 0 (1 ≤ i ≤ d); (PA3) φi = φ1 ∑i−1 h=0 θh−θd−h θ0−θd + (θ i − θ ∗ 0)(θi−1 − θd) (1 ≤ i ≤ d); (PA4) φi = φ1 ∑i−1 h=0 ...

OBJECTIVE The human sodium iodide symporter (hNIS) is a candidate autoantigen in autoimmune thyroid diseases. To investigate the possible existence of autoantibodies able to interfere with the biological activity of hNIS, an assay was developed using a cell line stably expressing hNIS. METHODS hNIS complementary cDNA cloned in pcDNA3 and a neomycin resistance gene vector were co-transfected i...

Sir, The Acinetobacter baumannii strain ATCC 17978 for which a genome sequence is available (GenBank accession number CP000521) was isolated in France in 1951, when antibiotic therapy was in its infancy. The sul1 sulphonamide resistance determinant and dfrA10 (dhfrX) trimethoprim resistance gene were reported to be present in this isolate. However, we were unable to find either gene in this gen...