Low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (MAPK) signaling pathways. It has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (CGNs). In this study, we have examined the activation of JNK, p38kinase and ERK1/2 pathways in low glucose medium in CGNs. The CGNs were prepared ...

ABSTRACT Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as that are sensed by MAP3 kinase Ask1, which in turn activates phosphorylation MAP kinases p38 and JNK. The sustained or high activation of these can result apoptosis, whereas short low promote regeneration. Using Ask1-dependent regeneration program, we demonstrat...

Purpose: To investigate whether the cytoprotective effect of anthocyanin (Anc) on oxygen-glucose deprivation/reperfusion (OGD/R)-induced cell injury is related to apoptosis signal-regulating kinase 1 (ASK1)/c-Jun N-terminal (JNK)/p38 signaling pathway.
 Methods: PC12 cells were pre-treated with various concentrations Anc (10, 50, and 100 ?g/mL) in OGD/R-induced model. The 3-(4, 5)-dimethyl...

urokinase plasminogen activator receptor (upar) and its ligands play a major role in many tumors by mediating extracellular matrix degradation and signaling cascades leading to tumor growth, invasion and metastasis. recently we introduced upar decapeptide antagonist with cytotoxic effect on mda-mb-231 cell line. in this study we assessed the alteration in upar downstream signaling following tre...

objective(s):hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. here, the protective effects of ferulic acid (fa) on hypoxia-induced neurotoxicity in pc12 cells were evaluated. materials and methods:we investigated the effect of fa on pc12 cells subjected to hypoxia stress, in vitro. results:fa increased cell viability, prevented membrane damage (ldh r...

Objective(s): Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reportedto be associated with many inflammatory mediators of PAH. This study aimed to evaluate the effect of chronic intermittent hypobaric hypoxia (CIHH) on pulmonary inflammat...

N-methyl-d-aspartate receptor (NMDAR) stimulation activates many downstream mechanisms involved in both cell survival and cell death. The manner in which the NMDAR regulates one of these pathways, the p38 mitogen-activated protein kinase (p38) pathway, is currently unknown. In the present study, we have defined a developmental-, concentration-, and time-dependent phosphorylation and subsequent ...

The mitogen-activated protein (MAP) kinase p38 is a key component of stress response pathways and the target of cytokine-suppressing antiinflammatory drugs (CSAIDs). A genetic approach was employed to inactivate the gene encoding one p38 isoform, p38 a . Mice null for the p38 a allele die during embryonic development. p38 a 1 / 2 embryonic stem (ES) cells grown in the presence of high neomycin ...

Fractalkine (FKN) is a chemokine with several roles, including chemotaxis; adhesion; and immune damage, which also participates in cell inflammation apoptosis responds to the pathogenesis of autoimmune diseases. Given involvement regulatory T cells (Treg) diseases, this study investigated mechanism FKN renal injury Treg via p38 mitogen-activated protein kinase (p38MAPK) signaling pathway lupus-...

One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was detected in all stages aortic valve sclerosis and demonstrated trigger activation p38 mitogen-activated protein kinase (p38 MAPK), which has been identified as a pro-inflammatory atherosclerosis. In this study, we investigated influence on IL-6 IL-33 induction, also impact calcification stenosis (AS). upregu...