نتایج جستجو برای: p15 gene

تعداد نتایج: 1142253  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Bailu Peng Jason B Fleming Tara Breslin Ana M Grau Shuichi Fojioka James L Abbruzzese Douglas B Evans Dan Ayers Kyle Wathen Tianai Wu Kimberly D Robertson Paul J Chiao

PURPOSE The tumor suppressor gene Smad4/DPC4, a key transcription factorin transforming growth factor beta (TGF-beta) signaling cascades,is inactivated in 50% of pancreatic adenocarcinomas. We seek to determine the role of Smad4/DPC4 in the suppression of tumor cell growth and in the regulation of TGF-beta-mediated expression of cell-cycle regulatory genes p15(ink4b) and p21(waf1). EXPERIMENT...

2002
Bailu Peng Jason B. Fleming Tara Breslin Ana M. Grau Shuichi Fojioka James L. Abbruzzese Douglas B. Evans Dan Ayers Kyle Wathen Tianai Wu Kimberly D. Robertson Paul J. Chiao

Purpose: The tumor suppressor gene Smad4/DPC4, a key transcription factor in transforming growth factor (TGF) signaling cascades, is inactivated in 50% of pancreatic adenocarcinomas. We seek to determine the role of Smad4/DPC4 in the suppression of tumor cell growth and in the regulation of TGF-mediated expression of cell-cycle regulatory genes p15 and p21. Experimental Design: Smad4/DPC4 is ov...

Journal: :Blood 1999
T Nakamura Y Yamazaki Y Hatano I Miura

The nucleoporin gene NUP98 was found fused to the HOXA9, HOXD13, or DDX10 genes in human acute myelogenous leukemia (AML) with chromosome translocations t(7;11)(p15;p15), t(2;11)(q35;p15), or inv(11)(p15;q22), respectively. We report here the fusion between the NUP98 gene and another homeobox gene PMX1 in a case of human AML with a t(1;11)(q23;p15) translocation. The chimeric NUP98-PMX1 transcr...

Journal: :Veterinary journal 2014
Aki Fujiwara-Igarashi Yuko Goto-Koshino Masahiko Sato Shingo Maeda Hirotaka Igarashi Masashi Takahashi Yasuhito Fujino Koichi Ohno Hajime Tsujimoto

The prognostic significance of the inactivation of the p16, p15, and p14 genes has been reported in lymphoid malignancies in humans. To evaluate the relationship between inactivation of the p16, p15, and p14 genes and prognosis in canine high-grade lymphoma, primary tumor cell samples obtained from 71 dogs with high-grade lymphoma were examined for the expression levels of these genes. Quantita...

Journal: :Blood 1995
Y Hatta T Hirama C W Miller Y Yamada M Tomonaga H P Koeffler

Adult T-cell leukemia (ATL) is associated with prior infection with human T-cell leukemia virus type I (HTLV-I). Twenty to 40 years often elapse from viral infection to overt ATL, suggesting that other genetic events must occur to produce frank leukemia. The p15 (MTS2) and p16 (CDKN2/MTS1) genes located on chromosome 9p have been implicated as candidate tumor-suppressor genes in several types o...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Journal: :Biophysical journal 2014
Alfredo De Biasio Alain Ibáñez de Opakua Tiago N Cordeiro Maider Villate Nekane Merino Nathalie Sibille Moreno Lelli Tammo Diercks Pau Bernadó Francisco J Blanco

We present to our knowledge the first structural characterization of the proliferating-cell-nuclear-antigen-associated factor p15(PAF), showing that it is monomeric and intrinsically disordered in solution but has nonrandom conformational preferences at sites of protein-protein interactions. p15(PAF) is a 12 kDa nuclear protein that acts as a regulator of DNA repair during DNA replication. The ...

Journal: :Reproductive biology 2012
Candela R Gonzalez Ricardo S Calandra Silvia I Gonzalez-Calvar

Adult hamsters exposed to short photoperiods show a marked atrophy of their internal reproductive organs, including a reduction in size, though not number of Leydig cells. Transforming growth factor-β1 (TGF-β1) is involved in the regulation of growth and proliferation of different cell types. The aim of the present study was to examine the influence of photoperiod on the protein and gene expres...

Journal: :Cancer research 2007
Eric Pasmant Ingrid Laurendeau Delphine Héron Michel Vidaud Dominique Vidaud Ivan Bièche

We have previously detected a large germ-line deletion, which included the entire p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the largest melanoma-neural system tumor (NST) syndrome family known to date by means of heterozygosity mapping based on microsatellite markers. Here, we used gene dose mapping with sequence-tagged site real-time PCR to locate the deletion end points, which were then ...

Journal: :Molecular and cellular biology 1997
M B Datto P P Hu T F Kowalik J Yingling X F Wang

The adenovirus early gene product E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth-inhibitory effects of the polypeptide hormone transforming growth factor beta (TGF-beta). The ability of TGF-beta to arrest cell growth in G1 correlates with the transcriptional induction of the cyclin-dependent kinase inhibitors, p15/INK4B and p21/WAF1/Cip1; ...

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