telencephalon at E9.5–10.5 and cortical ventricular zone later than E12.5. Otx, Tcf, Smad and two sites for unknown transcriptional factors are essential to all these activities. The enhancer is well conserved among tetrapods. The mutant that lacks this enhancer demonstrated that the Emx2 expression under this enhancer is indeed essential to diencephalon, telencephalon and cortical development....

Objectives: Bronchiectasis, a key pathology in CF, is characterised by abnormal, scarred and irreversibly dilated bronchi. Neutrophilic airway inflammation central feature of bronchiectasis, leading to high levels neutrophil-derived serine proteases, including neutrophil elastase (NE), proteinase-3 (PR3) cathepsin G (CatG) the sputum patients with CF bronchiectasis (CFBE). Serine proteases are ...