The central nervous system (CNS) of terrestrial vertebrates underwent a prominent molecular change when proteolipid protein (PLP) replaced P0 protein as the most abundant protein of CNS myelin. However, PLP did not replace P0 in peripheral nervous system (PNS) myelin. To investigate the possible consequences of a PLP to P0 shift in PNS myelin, we engineered mice to express PLP instead of P0 in ...

Let P (x) = pdx + . . . + p0 ∈ Z[x] be such that d ≥ 1, pd = 1, p0 ≥ 2 and N = {0, 1, . . . , p0 − 1}. We are proving in this note a new criterion for the pair {P (x),N} to be a canonical number system. This enables us to prove that if p2, . . . , pd−1, ∑d i=1 pi ≥ 0 and p0 > 2 ∑d i=1 |pi|, then {P (x),N} is a canonical number system.

We show that in the rat, the major gene of PNS myelin, P0, is expressed long before myelination in the neural crest, Schwann cell precursors, and embryonic Schwann cells irrespective of whether they will myelinate or not. This myelin-independent P0 expression is constitutive and likely to serve as a specific marker for the Schwann cell lineage. The much higher P0 expression accompanying myelina...

Let q be a prime with primitive root 2. We show that (a) if (pi) q−2 i=0 is a sequence of primes such that pi = 2pi−1 + 1 for all 1 ≤ i ≤ q − 2, then q divides p0 + 1 or p0 ∈ {2, 3, 5} and (b) if (pi) q−2 i=0 is a sequence of primes such that pi = 2pi−1 − 1 for all 1 ≤ i ≤ q − 2, then q divides p0 − 1 or p0 ∈ {2, 3}.

Differential targeting of myelin proteins to multiple, biochemically and functionally distinct Schwann cell plasma membrane domains is essential for myelin formation. In this study, we investigated whether the myelin protein P0 contains targeting signals using Madin-Darby canine kidney (MDCK) cells. By confocal microscopy, P0 was localized to MDCK cell basolateral membranes. C-terminal deletion...

The myelin P0 protein is glycosylated at a single site, asparagine 93, within its only immunoglobulin (Ig)-like domain. We have previously shown that P0 behaves like a homophilic adhesion molecule (Filbin, M. T., F. S. Walsh, B. D. Trapp, J. A. Pizzey, and G. I. Tennekoon. 1990. Nature (Lond.). 344:871-872). To determine if the sugar residues of this molecule contribute to its adhesiveness, the...

We consider a smooth Tonelli Lagrangian L : TTn → R and its viscosity solutions u(x, P ) characterized by the cell equation H(x, P + Dxu(x, P )) = H(P ), where H : T ∗Tn → R is the Hamiltonian associated with L. We will show that if P0 corresponds to a quasi-periodic Lagrangian invariant torus, then Dxu(x, P ) is Hölder continuous in P at P0 with Hölder exponent arbitrarily close to 1, and if b...

In mammals, protein zero (P0), a neural IgCAM, is expressed solely in the peripheral nervous system where it mediates self-adhesion of Schwann cell membranes as compact myelin is generated. We show that when P0 is expressed in HeLa, a cervical carcinoma cell line, cells regain adhesion-mediated growth control, including the acquisition of contact inhibition and loss of anchorage-independent gro...

A complex of three phosphoproteins (P0, P1 and P2) constitutes the stalk region at the GTPase center of the eukaryotic large ribosomal subunit, amongst which the protein P0 plays the most crucial role. Earlier studies have shown the functional complementation of the conditional P0-null mutant of Saccharomyces cerevisiae (W303dGP0) with orthologous P0 genes from fungal and mammalian organisms, b...

Evidence is emerging that the ability of the placenta to supply nutrients to the developing fetus adapts according to fetal demand. To examine this adaptation further, we tested the hypothesis that placental maternofetal transport of calcium adapts according to fetal calcium requirements. We used a mouse model of fetal growth restriction, the placental-specific Igf2 knockout (P0) mouse, shown p...