experimental  autoimmune  encephalomyelitis (eae)  is  a  mouse  model  for  multiple sclerosis (ms), this autoimmune disease is mainly mediated by adaptive and innate immune responses that lead to an inflammatory demyelination and axonal damage. imatinib mesylate is a  selective protein  tyrosine kinase inhibitor  with immunomodulatory  properties  that abrogates multiple signal transduction p...

objective(s):hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. here, the protective effects of ferulic acid (fa) on hypoxia-induced neurotoxicity in pc12 cells were evaluated. materials and methods:we investigated the effect of fa on pc12 cells subjected to hypoxia stress, in vitro. results:fa increased cell viability, prevented membrane damage (ldh r...

retention behavior of molecules mostly depends on their chemical structure. retention data of biologically active molecules could be an indirect relationship between their structure and biological or pharmacological activity, since the molecular structure affects their behavior in all pharmacokinetic stages. in the present paper, retention parameters (rm0) of biologically active 1,2-o-isopropyl...

background: interleukin (il)-8 plays important roles in the recruitment and activation of immune cells during visceral leishmaniasis (vl). genetic variations in il-8 modulate the expression of il-8 protein and may be associated with vl. this study aimed to evaluate polymorphisms at the il-8 −251 position in vl patients. methods: this cross-sectional study was performed on three groups: leishman...

due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (egcg), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of egcg on alleviation of hyperalgesia in streptozotocin-diabetic (stz-diabetic) rats. male wistar rats were divided into control, diabetic, egcg-treated-control and diabetic and sodium salicylate (ss...

fine particles silicoaluminophosphate-34 were synthesized by hydrothermal sol-gel method. the effect of crystallization time, as one of the important synthesis factors on particle size and crystallinity, kinetic and equilibrium adsorption, and selectivity of co2 / ch4 has been studied in this work. the adsorption isotherms are obtained at moderate gauge pressures (100-3000 kpa) and temperatures...

a l t h o u g h m o s t c o m p a n i e s s p e n d l e s s o n p r o d u c t d e s i g n, e x p e r i e n c e s h o w s t h a t, t h e s e c o m p a n i e s h a v e t o p a y h i g h e r c o s t s d u e t o p r o d u c t i o n p r o b l e m s o r l o s s o f m a r k e t. l i t e r a t u r e s t u d i e s s h o w t h a t t h e d e s i g n f o r s i x s i g m a i s a p o w e r f u l a p p r o a ...

background: child ho od cancer, as o n e of the life thre at ening and most serio u s health pro b lems, co n si d er a bly i n fl u en ce s the cogniti v e and soci a l functions of children with c ancer and the i r families; ho w e ver, sur p risin gl y e n ough, t h ese chil d ren are q u ite co mpatible w ith their pe ers and even fu n ction bet t er emotio n ally compa r ed with norm a l c...

objective: because of the importance iron metabolism and role of hepcidin in running, the present study investigates the effects of one event of submaximal exercise on plasma hepcidin concentrations in male runners. methods: for this purpose, we selected eight runners who were athletic team members of mazandaran university with an average age of 21.7±1.34 years, height of 175.6±5.88 cm, weight ...

in this study, a simple and low-cost method was developed for extraction and pre-concentration of brilliant blue(bb) and tropaeolin o(to) in food samples using cloud point extraction (cpe) prior to spectrophotometric determination. the effects of main factors such as ph, surfactant and salt concentrations, incubation time and temperature on the cloud point extraction of both dyes were investiga...