INTRODUCTION There are many factors that can affect the absorption process of orally administered drugs. Intestinal transporters play an important role in drug absorption. These transporters are divided into two major classes: the solute carriers and the ATP-binding cassette (ABC) transporters. P-glycoprotein (P-gp), belonging to the ABC transporter superfamily, flushes out the substrate drugs ...

We consider, for p ∈ (1, 2) and q > 1, the p-Laplacian evolution equation with absorption ut = div (|∇u|p−2∇u)− u in R × (0,∞). We are interested in those solutions, which we call singular solutions, that are non-negative, non-trivial, continuous in Rn × [0,∞) \ {(0, 0)}, and satisfy u(x, 0) = 0 for all x = 0. We prove the following: (i) When q ≥ p− 1 + p/n, there does not exist any such singul...

Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 microM) and low for naphthoquine (5 microM). With 20 microM naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.

Fe absorption was estimated in adults and infants from the erythrocyte incorporation of Fe isotopes added to infant formula. Fe absorption was measured in adults using radioisotopes, and in infants with a stable-isotope technique. In adults, the geometric mean Fe absorption from a ready-to-feed soya formula with its native phytic acid content was 2.4%. This increased to 6.0% (P < 0.05) after al...

'Klemp P, Staberg B, Madsbad S, Kolcndorf K. Smoking reduces insulin absorption from subcutaneous tissue. Br MedJ' 1982;284:237. 2 Binder C. Absorption of injected insulin. Acta Pharmacol Toxicol (Copenh) 1969 ;27(suppl 2): 1-84. 3Berger M, Cuppers HJ, Hegner H, Jorgens V, Berchtold P. Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care 1982;5...

INTRODUCTION Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric emptying (GE) and absorption has hitherto not been evaluated. The aim of this study was to quanti...

BACKGROUND It is assumed that calcium absorption decreases with age, but this is not well documented. We report a study that addresses this issue. OBJECTIVE The aim was to establish the extent and timing of any age-related change in calcium absorption in postmenopausal women. DESIGN We measured radiocalcium absorption (alpha) in 262 healthy postmenopausal women aged 40-87 y. We also measure...