Objective(s):Transforming growth factor-β(TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell li...

Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular re...

Epithelial-mesenchymal crosstalk is vital for balancing expansion and regression of the progenitor cell pool during tissue turnover. In hair growth cycle, little known about mechanisms underlying regulated death follicle that precedes each regeneration re-growth. Here, we discover dermal sheath smooth muscle, which lines all follicles, controls via transforming factor (TGF)-β mechanosignaling. ...

Abstract Lactoferrin (LF) is known to possess anti-inflammatory activity, although its mechanisms of action are not well-understood. The present study asked whether LF affects the commitment inducible regulatory T cells (Tregs). substantially promoted Foxp3 expression by mouse activated CD4+T cells, and this activity was further enhanced TGF-β1. Interestingly, blocking TGF-β with anti–TGF-β Ab ...

an appropriate differentiation of distinct human cd4+ t cell subset is critical for manipulating these cells for using in immunity related diseases. despite various attempts to clarify the role of different factors involved in th17 differentiation, many crucial contradictions yet remained to be optimized. although it has been shown that the differentiation of in-vitro th17 cells culture conditi...

Breast cancer progression and metastasis have been linked to abnormal signaling by transforming growth factor-β (TGF-β) cytokines. In early-stage breast cancers, TGF-β exhibits tumor suppressor activity by repressing cell proliferation and inducing cell death, whereas in advanced-stage tumors, TGF-β promotes invasion and metastatic dissemination. ...

Background: Transforming growth factor β (TGF-β) arrests many cell types in the G1 phase of the cell cycle and upregulates plasminogen activator inhibitor 1 (PAI-1). The type I (TGF-βRI) and II (TGF-βRII) TGF-β receptors mediate these and other effects of TGF-β on target cells. TGF-β initially binds to TGF-βRII and subsequently TGF-βRI is recruited to form a heteromeric complex. TGF-βRI phospho...

TGF-β is required for both Foxp3(+) regulatory T cell (Treg) and Th17 commitment. Plasmacytoid DCs (pDC) have been shown to participate to both Treg and Th17 commitment as well. However, few studies have evaluated the direct effect of TGF-β on pDC, and to our knowledge, no study has assessed the capacity of TGF-β-exposed pDC to polarize naive CD4(+) T cells. In this paper, we show that TGF-β-tr...

Transforming growth factor β (TGF-β) is involved in cellular processes including growth, differentiation, apoptosis, migration, and homeostasis. Generally, TGF-β is the inhibitor of cell cycle progression and plays a role in enhancing the antagonistic effects of many growth factors. Unlike the antiproliferative effect of TGF-β, E2, an endogeneous estrogen, is stimulating cell proliferation in t...