Oxylipins are oxidised fatty acids that can exert lipid mediator functions in inflammation, and several oxylipins derived from arachidonic acid are linked to asthma. This study quantified oxylipin profiles in different regions of the lung to obtain a broad-scale characterisation of the allergic asthmatic inflammation in relation to healthy individuals. Bronchoalveolar lavage fluid (BALF), bronc...

Jasmonic acid and related oxylipins are controversially discussed to be involved in regulating the initiation and progression of leaf senescence. To this end, we analyzed profiles of free and esterified oxylipins during natural senescence and upon induction of senescence-like phenotypes by dark treatment and flotation on sorbitol in Arabidopsis (Arabidopsis thaliana). Jasmonic acid and free 12-...

The oxygenated derivatives of fatty acids, known as oxylipins, are pivotal signaling molecules in animals and terrestrial plants. In animal systems, eicosanoids regulate cell differentiation, immune responses, and homeostasis. In contrast, terrestrial plants use derivatives of C18 and C16 fatty acids as developmental or defense hormones. Marine algae have emerged early in the evolution of eukar...

Oxylipins function as signaling molecules in plant growth and development and contribute to defense against stress. Here, we show that oxylipins also facilitate infestation of Arabidopsis thaliana shoots by the phloem sap-consuming green peach aphid (GPA; Myzus persicae), an agronomically important insect pest. GPAs had difficulty feeding from sieve elements and tapping into the xylem of lipoxy...

Oxidized fatty acids, termed oxylipins, are an important class of signaling molecule in plants, especially related to plant stress responses and innate immunity. The bestcharacterized oxylipins are jasmonic acid (JA) and its immediate precursor 12-oxophytodienoic acid (OPDA), which are formed enzymatically and accumulate in response to various stresses, in particular wounding and pathogen infec...

Methods Oxylipins were extracted from 197 cord blood plasma samples from the ENVIRONAGE (ENVIRonmental influence ON AGEing in early life) birth cohort in Belgium. Thirty-seven specific oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15LOX) and cytochrome P450 (CYP) metabolic pathways were quantified by ultra-performance liquid chromatography coupled to electrospray ion...

BACKGROUND As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology. OBJECTIVES We studied the association between in utero PM2.5 (particulate matter with aerodynamic diameter < 2.5 μm) exposure and oxylipi...

Enzymatic and non-enzymatic peroxidation of polyunsaturated fatty acids give rise to accumulation of aldehydes, ketones, and α,β-unsaturated carbonyls of various lengths, known as oxylipins. Oxylipins with α,β-unsaturated carbonyls are reactive electrophile species and are toxic. Cells have evolved several mechanisms to scavenge reactive electrophile oxylipins and decrease their reactivity such...

neurodegenerative disease are characterized by the progressive loss of neurons from specific origins of the cns .alzheimer disease (ad) is a neurodegenerative disorder which affect brain regains that control memory and ability to learn. it is estimated that 27 million people are affected word wide and this number is expected to triple by 2050 due to increase of the population life expectancy. a...