OBJECTIVE To compare the estimated first-line treatment costs of extended-release tolterodine versus controlled-release oxybutynin in patients with overactive bladder (OAB). METHODS We developed a decision-analysis model to estimate the patterns of treatment, resource consumption, and cost impact of treating OAB with either controlled-release oxybutynin or extended-release tolterodine as firs...

BACKGROUND Selective serotonin reuptake inhibitors are primarily used in the pharmacological treatment of patients experiencing a major depressive disorder. However, one of the common unwanted effects is excessive sweating or hyperhidrosis. Oxybutynin is an anticholinergic medication which reduces sweating. The aim of this double-blind study was to examine the effect of administration of oxybut...

BACKGROUND To evaluate the effectiveness and patient satisfaction with the use of oxybutynin for treating axillary hyperhidrosis in a large series of patients. METHODS One hundred two patients with axillary hyperhidrosis were treated with oxybutynin. During the first week, patients received 2.5 mg of oxybutynin once a day in the evening. From the 8th to the 42nd day, they received 2.5 mg twic...

BACKGROUND In 2014, the US Food and Drug Administration (FDA) initiated a prospective routine surveillance using the Mini-Sentinel (M-S) program to assess potential signals of acute myocardial infarction (AMI) and stroke with use of mirabegron, indicated for the treatment of overactive bladder (OAB), compared with oxybutynin. PURPOSE To replicate the FDA M-S analysis of mirabegron using datas...

background: primary nocturnal enuresis is a common disorder that often leads to considerable distress in affected children and their family. in many countries pharmacologic therapy is preferred to non-pharmacologic behavioral and conditional alarm therapy. imipramine, oxybutynin, and desmopressin have been used for enuresis with various efficacies. the aim of the present study was to compare th...

conclusions there is no significant difference between monotherapy with desmopressin, imipramine or oxybutynin in children with enuresis. however, oxybutynin showed a higher response rate and a lower relapse rate compared to other medications. more clinical trials with a larger sample size are needed to clarify these uncertainties. results children in the oxybutynin group showed a slightly high...

Hyperhidrosis is a disorder of excessive sweating severely impacting on patient's quality life (Qol). Several studies have been published about oral oxybutynin, but no focused the achievement complete clinical and Qol response. The aim this study was to report our real-life experience with oxybutynin in patients severe hyperhidrosis significantly affecting their Qol. In cohort retrospective stu...

1. Del Boz J. Tratamiento sistémico de la hiperhidrosis. Actas Dermosifiliogr. 2015;106:271--7. 2. Toledo-Pastrana T. Nuevas perspectivas en hiperhidrosis. Piel. 2016;31:360--4. 3. Schollhammer M, Brenaut E, Menard-Andivot N, Pillette-Delarue M, Zagnoli A, Chassain-Le Lay M, et al. Oxybutynin as a treatment for generalized hyperhidrosis: A randomized, placebo-controlled trial. Br J Dermatol. 20...

OBJECTIVES This case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution. METHODS A 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was ...