background: considerable evidence suggests that oxidative stress affects diabetes mellitus (dm) and contributes to its complications. vitamin d has been shown to possess antioxidant properties. the aim of this study was to determine the association between serum levels of calcifediol (25-oh-d), an indicator of vitamin d status, and lipid profiles with oxidative stress in patients with type 2 di...

Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuri...

atherosclerosis is a chronic inflammatory condition that affects the arterial wall. oxidized low- density lipoprotein (ox-ldl) seems to have an important role in atherosclerotic plaque formation. this study was performed to investigate the effects of ox-ldl as well as pha on proliferation and gene expression of  peripheral blood  mononuclear  cells (pbmcs) in patients with atherosclerosis compa...

objective(s) oxidized low-density lipoproteins (ox-ldls) appear to play a significant role in atherogenesis. in fact, circulating ox-ldl concentrations have been recognized as a risk factor for cardiovascular disease (cvd). the main objectives of this study were to assess the effects of antioxidant vitamins on ox-ldl as a biomarker of cvd in male subjects with cvd risk factors. materials and me...

The human lectin-like oxidized low density lipoprotein receptor 1 LOX-1, encoded by the ORL1 gene, is the major scavenger receptor for oxidized low density lipoprotein in endothelial cells. Here we report on the functional effects of a coding SNP, c.501G>C, which produces a single amino acid change (K>N at codon 167). Our study was aimed at elucidating whether the c.501G>C polymorphism changes ...

A specific lectin-like endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In this study, we examined the regulation of LOX-1 by oxidized low density lipoprotein (ox-LDL) and determined the role of LOX-1 in ox-LDL-induced apoptosis of cultured human coronary artery endothelial cells (HC...

A specific lectinlike endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In this study, we examined the regulation of LOX-1 by oxidized low density lipoprotein (ox-LDL) and determined the role of LOX-1 in ox-LDL–induced apoptosis of cultured human coronary artery endothelial cells (HCA...

BACKGROUND Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown. Abnormalities in essential fatty acid metabolism, free radical generation, lipid peroxidation, and release of lymphokines have been proposed. OBJECTIVE Our purpos...

Received June 24, 2008. Accepted January 28, 2009. Corresponding author: Azize Sener, Department of Biochemistry, Faculty of Pharmacy, Marmara University, Tibbiye Cad., No: 49, 34668, Haydarpasa-Istanbul, Turkey. Phone: +90 216 414 29 62; e-mail: [email protected] Abbreviations: apoB100 – apolipoprotein B100, apoER2 – apolipoprotein E receptor 2, FITC – fluorescein isothiocyanate, GpIIb/ I...