accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. nadph oxidase has been recognized as a major source of oxidative stress in vasculature. however, the relation between nadph oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. the present study aimed to investigate the rele...

neurodegeneration is a complex and multifaceted process leading to many chronic disease states. a conventional definition implies a progressive neuronal death, which usually affects a specific population of nerve cells the vulnerability of which determines the clinical manifestations of a particular neurodegenerative disease. the neurodegenerative process is associated with many events. each ev...

selenium plays an important role in biological system due to its incorporation in glutathione peroxidases and thioredoxin reductase as prosthetic group, the pharmacological studies of synthetic organoseleno-compounds revealed these molecules to be used as antioxidants, enzyme inhibitors, neuroprotectors, antitumor, anti-infectious agents, cytokine inducers and immuno-modulators. the present stu...

different contraceptive methods are used by breastfeeding mothers. in general, these methods are classified into two major groups, hormonal and non-hormonal. a number of studies have shown that combined oral contraceptive pills may adversely affect the quality and the quantity of human milk. in other studies it has been shown that estrogen and progesterone seem to reduce the risk of cardiac and...

objective(s):   zinc oxide nanoparticles (znp) are increasingly used in sunscreens, biosensors, food additives and pigments. in this study the effects of znp on liver of rats was investigated.     materials and methods: experimental groups received 5, 50 and 300 mg/kg znp respectively for 14 days. control group received only distilled water. alt, ast and alp were considered as biomarkers to ind...

objective(s):one cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. it has been shown that chinese green tea (cgt) (lung chen tea) has higher antioxidant property than black tea. in this paper, we will explore the preventive effect of cgt on cigarette smoke-in...

background: it has been reported that ischemia-reperfusion is associated with augmentation of oxidative stress and its specific and sensitive markers. oxidative stress may cause atrial fibrillation (af) which is a common consequence after cardiac surgery. dietary supplementation with antioxidants might lower the incidence of af following coronary artery bypass graft (cabg) surgery. materials an...

many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. to review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from international medical jou...