objective(s): we aimed to study the effect of trimetazidine (tmz) on urethral wound repair. materials and methods: a total of 52 male rats were used; 8 groups were formed: 1-week and 3-week control (c1,c3), sham (s1, s3), oral (ot1, ot3), and intraurethral tmz (iut1, iut3) groups. serum and urine total antioxidant capacity (tac), total oxidant capacity (toc), and 8-hydroxy-deoxy-guanosine (8-oh...

objective(s):previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (stz)-induced diabetic rats. recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. howev...

aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis. recent studies suggest that aldo can cause microvascular damage, oxidative stress and endothelial dysfunction. however, its exact cellular mechanisms remain obscure. this study was undertaken to examine the effect of aldo on superoxide production in human umbilical artery endothelial cells (h...

malondialdehyde (mda) is widely used as a biomarker for assessing oxidative stress in biomedical fields. lipid peroxidation is a chain phenomenon resulting in the formation of various active compounds that result in cellular damage. biomonitoring of mda has been used in both in-vivo and in-vitro studies as a key biomarker for various disease patterns including hypertension, diabetes, atheroscle...

background: lipid peroxidation is a free radical-generating process which occurs on every membranous structure of the cell. free radicals are known to be involved in a number of human pathologies including atherosclerosis. the purpose of this cross-sectional study was to examine the association between pre-hypertension status and oxidative stress markers [total antioxidant capacity (tac) and ma...

silicon (si) is considered as one of the beneficial elements for plants that play important roles in plant resistance to stresses. in this experiment, the effects of three levels of silicon (0, 0.85 and 1.7 mm) on the growth and physiological processes of pumpkin were studied in plants inoculated with sphaerotheca fuliginea (250000 conidia ml−1) and non-inoculated plants under hydroponic condit...

background: the pathogenesis of ethanol in the liver and kidney is associated with an increase in free radicals and oxidative stress that leads to structural and functional abnormalities in these vital organs. methods: forty-eight male wistar rats were placed in eight groups and were treated as follows: control group (normal saline), group of ethanol (4 g/ kg), three doses of ardeh and honey co...

objective: inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. materia...

background: acetaminophen (apap) overdose causes renal and hepatic injury. it is ‎also believed that oxidative stress has a pivotal role in apap-induced renal injury. ‎therefore, protective effects of different antioxidants have been examined in apap-‎induced renal and hepatic toxicity models. stevia rebadiana is a plant with a high ‎degree of natural antioxidant activity in its leaf extract. t...

background: nonalcoholic steatohepatitis (nash), a progressive stage of nonalcoholic fatty liver disease (nafld), is characterized by steatosis with inflammation. investigations have suggested that oxidative stress may play an important role in the progress of nafld to nash. to provide further insights into beneficial effects of antioxidants in nash prevention, we employed two manganese-superox...