The objective of this case report is to present a case of primary ovarian insufficiency in 17 year old, single girl, who had Acute Lymphocytic Leukemia (ALL) and was treated with chemo and radiotherapy, followed by bone marrow transplant from her HLA matched brother. The patient was treated at King Abdulaziz Medical City, Riyadh, Saudi Arabia. She was diagnosed with primary ovarian insufficienc...

Introduction and purpose: Premature Ovarian Insufficiency (POI) is a rare but serious disease diagnosed in about 1% of women before the age 40. It characterized by hypoestrogenism an increase level follicle-stimulating hormone, which associated with menstrual disorders, pregnancy failures reduced quality life. The main causes POI include genetic background autoimmune abnormalities, as well incr...

Background The purpose of this study was to evaluate the ability of poor ovarian response criteria to classify women presenting with infertility and oligomenorrhea as having "occult" premature ovarian insufficiency. Methods This was a cross sectional study conducted at Aziz Medical Center, Karachi, Pakistan from 1st August 2015 to 31st July 2016. Women with infertility and oligomenorrhea were...

introduction: primary ovarian failure (pof) is a syndrome composed of amenorrhea, estrogen deficiency and follicular stimulating hormone (fsh) of menopausal ranges in young women. in this article, we report a case of primary amenorrhea that presented with full term pregnancy.case presentation: a 29-year old woman with a history of primary amenorrhea attended hospital with full term pregnancy. s...

OBJECTIVE Steroidogenic factor 1 (SF-1/NR5A1) plays a crucial role in regulating adrenal development, gonad determination and differentiation, and in the hypothalamic-pituitary control of reproduction and metabolism. In men (46, XY), it is known that mutations in SF-1/NR5A1 gene cause a wide phenotypic spectrum with variable degrees of undervirilization. In recent years, the role of SF-1 in the...

Objective: To evaluate whether systemic inflammatory markers (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and red blood cell distribution width (RDW) to platelet ratio (RPR)) can be used as reliable markers for the diagnosis of premature ovarian insufficiency (POI) and to determine if there is a relationship between these markers and follicle stimulating hormone (FS...

With the increasing numbers of survivors of cancer in young people, future fertility and ovarian function are important considerations that should be discussed before treatment commences. Some young people, by nature of the treatment they will receive, are at high risk of premature ovarian insufficiency and infertility. For them, ovarian tissue cryopreservation (OTC) is one approach to fertilit...