Ovulation has long been associated with an increased risk in ovarian cancer, yet the underlying molecular mechanisms remain obscure. Two aspects of ovulation have been linked to ovarian cancer pathogenesis. The first is the impact of repetitive tissue injury and repair that occurs with each ovulatory event. The second is the release of follicular fluid that accompanies the follicular rupture an...

introduction: the role of ovarian hormones and nitric oxide (no) in learning and memory and their interaction has been widely investigated. the present study carried out to evaluate different effect of l-name on spatial learning and memory of ovariectomized (ovx) and sham operated rats. methods: 32 rats were divided into 4 groups: 1) sham 2) ovx 3) sham-ln and 4) ovx-ln. the animals of groups 3...

Background. Hormone disorders, stress-oxidative and inflammation in ovarian tissue cause no- ovulation in women with polycyclic ovarian syndrome (PCOS). Several studies have shown the role of exercises in control of sex hormones. Objectives. The aim of this study was to investigate the effect of 6 weeks of swimming training (ST) on serum levels of sex hormones, antioxidant enzymes and oxidativ...

1. On Day 10 of the oestrous cycle in pigs, after laparotomy noradrenaline (NA), methoxamine (alpha 1-adrenomimetic, M), Prazosin (alpha 1-adrenolytic, Pr) in total doses of 4 mumol, and saline were infused (10 min) into the superficial layer of mesovarium on both sides of the ovarian pedicle vasculature, close to the ovary. 2. Blood flow in the ovarian artery, heart rate and progesterone (P4) ...

Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epit...

Edgar Allen identified and outlined the role of female sex hormones [2] and discovered estrogen [3] in the early 1900s in the US. In 1923, Allen, through his research with mice, isolated the primary ovarian hormone [4], later renamed estrogen [3], from ovarian follicles and tested its effect through injections in the uterine tissues of mice. Allen's work on estrogen [3], enabled researchers to ...

Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are responsible for the observed gender-associated differences in arterial blood ...

Cyclic adenosine monophosphate (cAMP)-related intracellular mechanisms can be important in the control of reproductive processes. The aim of the present study was to examine possible hormonal and intracellular mechanisms mediating the action of cAMP on ovarian cell functions, in particular the mechanisms of stimulatory action of dbcAMP on rabx and caspase 3), plasma level of progesterone and es...