A technique for measuring resistance to outflow in enucleated eyes is described. The technique minimizes the artifactual effects of ocular stretching and anterior chamber deepening. Using this perfusion technique, it was found that the resistance to outflow in normal, enucleated human eyes increases directly and linearly with intraocular pressure. This phenomenon, termed the outflow obstruct...

The clinical and haemodynamic findings in a patient with hypertrophic obstructive cardiomyopathy and severe left ventricular outflow obstruction are presented. Treatment with an increasing dose of orally administered practolol up to a maximum of 1200 mg a day, resulted in symptomatic improvement, and abolition of the resting gradient when the patient was recatheterized six months later.

Introduction Conclusions References

Like all fluids, blood tends to flow from areas of high pressure to low pressure. This seemingly trite observation hides a great deal of sophisticated pathophysiology that we are only beginning to exploit diagnostically and potentially therapeutically. In this issue of Circulation, Yotti and colleagues have exploited a new noninvasive technique to measure the small pressure differences generate...

Edmund Kenneth Kerut, M.D.,∗ Curtis Hanawalt, R.D.C.S.,† Marie Dearstine, R.D.C.S., ‡ Robert Frank, M.D.,§ and Charles Everson, M.D.§ ∗Heart Clinic of Louisiana, Marrero, Louisiana, Departments of Physiology and Pharmacology, LSU Health Sciences Center, New Orleans, Louisiana, †Cardiac and Vascular Imaging Center, West Jefferson Medical Center, Marrero, Louisiana, ‡Cardiology Department, Ochsne...

Aqueous humor outflow resistance is the primary determinant of intraocular pressure (IOP), and increased outflow resistance is the basis for elevated IOP associated with glaucoma. Experimental evidence suggests that the bulk of outflow resistance is generated in the vicinity of the inner wall endothelium of Schlemm's canal, its basement membrane and the juxtacanalicular connective tissue (JCT)....

The effect of corticosteroids on aqueous humor (AH) formation rate and outflow facility was measured in the cat eye. AH formation rate was determined by continuous posteroanterior chamber perfusion with an AH-like buffer containing inulin-C*. It was found that the total quantity of inulin-C recovered through the anterior chamber outflow cannula could be used to estimate changes in outflow facil...

[1] Ionospheric outflow has been shown to be a significant contributor to the plasma population of the magnetosphere during active geomagnetic conditions. We present the results of new efforts to model the source and effects of out-flowing plasma in the Space Weather Modeling Framework (SWMF). In particular, we develop and use the Polar Wind Outflow Model (PWOM), a field-aligned, multifluid, mu...