The grammaticalization literature notes the cross-linguistic robustness of a diachronic pattern involving the aspectual categories resultative, perfect, and perfective. Resultative aspect markers often develop into perfect markers, which then end up as perfect plus perfective markers. We introduce supporting data from the history of Old and Middle Indo-Aryan languages, whose instantiation of th...

The grammaticalization literature notes the cross-linguistic robustness of a diachronic pattern involving the aspectual categories resultative, perfect, and perfective. Resultative aspect markers often develop into perfect markers, which then end up as perfect plus perfective markers. We introduce supporting data from the history of Old and Middle Indo-Aryan languages, whose instantiation of th...

We tested the hypothesis that exercise training (Ex) attenuates the effects of hypercholesterolemia on endothelium-dependent relaxation in left anterior descending coronary arteries. Adult female pigs were fed a normal-fat (NF) or high-fat (HF) diet for 20 wk. Four weeks after the diet was initiated, pigs were trained or remained sedentary (Sed) for 16 wk, yielding four groups of pigs: 1) NF-Se...

Because the regulation of vascular function involves complex mutual interactions between nitric oxide (NO) synthase (NOS) and cyclooxygenase (COX) products, we examined the contribution of NO and prostanoids derived from the COX pathway in modulating aortic baroreceptor resetting during an acute (30 min) increase in arterial pressure in anesthetized rats. Increase in pressure was induced either...

L-NAME (LN) induces hypertension by blocking nitric oxide (NO) synthesis. It produces vascular hyperreactivity to phenylephrine (PHE) associated with a reduced vascular Na+, K+-ATPase activity. The aim of this work was to investigate whether products of the cyclooxygenase pathway are involved in alterations of vascular reactivity and Na+-pump activity in the tail artery from LN-induced hyperten...

A growing body of experimental evidence suggests that neutrophilic polymorphonuclear leukocyte (PMN)-endothelial cell interactions play a critical role in the pathophysiology of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy. The objective of this study was to directly determine whether the expression of endothelial cell adhesion molecules is enhanced in a model of NSAID-induce...

Introduction Conclusions References