Here we present a novel dynamic organocatalyst, based on a first-generation molecular motor core, able to control the stereochemical outcome of the Henry reaction using both light and heat as external stimuli.

A novel α-oximation reaction of unactivated aldehydes has been achieved in excellent yields by reaction with NaNO(2)-FeCl(3) couple and in the presence of pyrrolidine as organocatalyst.

An asymmetric 5-endo chloroetherification of homoallylic alcohols is successfully developed that employs an easily available quaternary ammonium salt derived from cinchonine as a conventional organocatalyst. This approach provides ready access to β-chlorotetrahydrofurans in high enantioselectivities.

The six-pots synthesis of latanoprost has been accomplished with excellent diastereo- and enantioselectivities through an organocatalyst-mediated Michael reaction, a substrate-controlled intramolecular Mukaiyama aldol reaction as key steps.

1,1’-(Ethane-1,2-diyl)dipyridinium bistribromide (EDPBT) was used as a chemoselective and effective organocatalyst for the silylation of hydroxyl groups as well as desilylation of trimethylsilyl ethers under mild conditions at room temperature with good to excellent yields.

The field of organocatalysis has blossomed over the past few decades, becoming an alternative to transition-metal catalysis or even replacing the realm of transition-metal catalysis. However, a truly powerful organocatalyst with a high turnover number (TON) and turnover frequency (TOF) while retaining high enantioselectivity is yet to be discovered. Similar to metal catalysis, extremely low cat...

An axially chiral styrene-based organocatalyst, featuring a combination of structure and pyrrole ring, has been designed synthesized. This catalyst demonstrates remarkable capabilities in producing a...

a water soluble, bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally friendly gre...

The use of a bifunctional cinchona/thiourea organocatalyst for the direct and α-stereoselective glycosylation of 2-nitrogalactals is demonstrated for the first time. The conditions are mild, practical, and applicable to a wide range of glycoside acceptors with products being isolated in good to excellent yields. The method is exemplified in the synthesis of mucin type Core 6 and 7 glycopeptides.

A novel cinchona-alkaloid-derived organocatalyst has been developed to catalyze the asymmetric regioselective [3+2] cycloaddition of 3-isothiocyanato oxindoles with dibenzylidene ketones. A series of spirooxindole enols could be obtained in high yields with good-to-excellent diastereo- and enantioselectivities.