Abstract The protective bronze film was prepared by mixing the reaction product of oligosaccharide (COS) and modified tannic acid (TA) with polyvinyl alcohol polyethylene glycol. Chloroacetic to carboxylate TA used generate sodium tannate. N,N’-Dicyclohexylcarbodiumide (DCC)/1-Hydroxybenzotriazole (HOBt) as a condensing agent form an amide bond between carboxylic amine COS-TA. synthesized chara...

Introduction. We have recently reported the application of phosphonium and uronium acti vating reagents to the preparation of silica poly mer supports for solid phase oligonucleotide syn thesis [1]. Both elongation of the polyamide link ers and attachment of nucleosides to the poly mers were performed in the presence of onium coupling reagents BOP and HBTU originally developed for peptide synth...

On the basis of potent HDAC-inhibitory activity and anticancer activity of SAHA, novel SAHA derivatives 3a-d and 7 with a bulky cap such as p-dimethylaminophenyl, 4-phenylaminophenyl, 4-phenyloxyphenyl, 9Hfluorenyl or naphthalenyl ring were synthesized starting from the corresponding aryl amines or naphthalenyl acetic acid using an EDC-mediated amide coupling reaction in the presence of HOBt fo...

A series of 5-sulphanyl derivatives of 1-Benzyl-2-alkyl-4-nitro-1H-imidazoles (5-9) were prepared by the coupling method of 3-(1-Benzyl-2-ethyl-4-nitro-1H-imidazole-5ylsulfanyl)propanoic acid (4) with appropriate amino acid ester hydrochloride, in the presence of hydroxybenzotriazole (HOBT) and DCC. Compounds (10-12) and (13) were similarly synthesized using appropriate amino alcohols, and 1-su...

“Prodrugs Approach” is a versatile approach in solving the problems associated with drug molecules. Diclofenac is a pain reliever in variety of painful conditions but it has some side effects i.e. absorption, toxicity, distribution, instability, formulation etc. These side effects can be reduced by “Prodrugs Approach”. In the present research work some amide Prodrugs of Diclofenac have been syn...

Phthalic, maleic and succinic anhydrides have been reacted with aromatic amines to obtain the corresponding monoacid monoamides. The latter have been each transformed into the corresponding cyclic imide derivatives by treating with SOCl2. Alternatively, anhydrides have been reacted with methanolic KOH to obtain monomethyl ester derivatives which on reaction with aromatic amines in the presence ...

Polymers, based on Poly L-lactic acid (L-PLA) and coupled with β-Cyclodextrin (β-CD), have been used for the preparation of microspheres for drug encapsulation. The strategy was based on the modification of the terminal carboxylic group of L-PLA (73.000) by coupling it with a β-CD in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation was found to be 80%. Char...