To the Editor: The present strategy of avoidance and epinephrine autoinjection for severe IgE-mediated food reactions is not always successful.1,2 This may be even truer for young children, who cannot read and have to depend on adults to administer the epinephrine. The following case report illustrates such a failure in a young child and describes a treatment that can be performed by an allergy...

A 45-year-old black woman, sputum positive for acid-fast bacilli, developed hypersensitivity to both isoniazid and rifampin. She was admitted to the hospital and desensitized to both medications using modified penicillin protocols. Skin testing was negative to both drugs. Desensitization to isoniazid was complicated by a drug fever that was controlled by prednisone. The patient was able to main...

hours of cow’s milk ingestion, skin prick tests $3 mm, and serum specific IgE levels $0.35 kU/L for whole cow’s milk, casein, a-lactalbumin, or b-lactoglobulin. Persistence of CMP allergy in the 4 weeks before tolerance induction was based on positive skin and serum testing and a positive double-blind placebo-controlled food challenge to cow’s milk. Exclusion criteria included anaphylactic shoc...

BACKGROUND Aspirin desensitization improves clinical outcomes in most patients with aspirin-exacerbated respiratory disease. Most protocols for desensitization are time-consuming. OBJECTIVE Our objective was to use historical information about the course of aspirin desensitization to enhance the efficiency of the desensitization protocol. METHODS Four hundred twenty subjects with suspected ...

IgE-mediated cow's milk allergy (CMA) is a heavy burden for patients, particularly for children and their families. Allergen avoidance represents the only therapeutic option, but oral desensitization protocols have been suggested. Because of the long duration and complexity of these protocols we examined the feasibility of an oral tolerance induction protocol using a weekly up-dosing schedule. ...

A renewed interest in oral desensitization as treatment for food allergy has been observed in the last few years. We studied a novel method based on the end point skin prick test procedure to establish the starting dose for oral desensitization in a group of 30 children highly allergic to milk. The results (in terms of reactions to the first dose administered) were compared with a group of 20 c...

OBJECTIVES We hypothesized that a standardized outpatient clopidogrel desensitization protocol would be safe and effective. BACKGROUND Adverse reactions to clopidogrel are not uncommon, and affected patients must switch to ticlopidine after drug-eluting stent placement, despite its more malignant side-effect profile, because of the risk of ischemic events associated with premature discontinua...