Over a third of oral bacteria are as-yet-uncultivated in-vitro. Siderophores have been previously shown to enable in-vitro growth of previously uncultivated bacteria. The objective of this study was to cultivate novel oral bacteria in siderophore-supplemented culture media. Various compounds with siderophore activity, including pyoverdines-Fe-complex, desferricoprogen and salicylic acid, were f...

We evaluated a three-dimensional (3D) human oral cell culture that consisted of two types of cells, oral keratinocytes and fibroblasts as a model of oral mucositis which is a debilitating adverse effect of chemotherapy and radiation treatment. The 3D cell culture model was irradiated with 12 or 2 Gy, and total RNA was collected 6 h after irradiation to compare global gene expression profiles vi...

CHROMagar Candida is a new chromogenic culture medium that is used for the isolation and direct identification of some of the most clinically important yeast pathogens on the basis of colony colour. The aim of the study was to isolate and identify Candida species from the oral cavity with CHROMagar Candida. Samples (158) from 68 orthodontic patients wearing upper removable orthodontic applianc...

Culture dependent and culture independent methods have shown that about 600 species of bacteria inhabit the human oral cavity. While some oral microorganisms have a direct link to dental caries, periodontal disease and halitosis, opportunistic pathogens may be responsible for systemic diseases such as bacterial endocarditis, aspiration pneumonia, osteomyelitis in children, preterm low birth wei...

The aim of this study is to investigate the effects of cold atmospheric pressure plasma (CAP)-induced radicals on the epidermal growth factor receptor (EGFR), which is overexpressed by oral squamous cell carcinoma, to determine the underlying mechanism of selective killing. CAP-induced highly reactive radicals were observed in both plasma plume and cell culture media. The selective killing effe...

Triphala is an ayurvedic herbal formulation consisting of the dried fruits of three medicinal plants Terminalia chebula, Terminalia belerica, and Phyllanthus embelica which has antimicrobial, anti-oxidant, and anti-inflammatory property. The aim of this study was to evaluate the efficacy of Triphala against oral pathogens. The standard stock culture of microorganisms was isolated from 20 patien...

In the 1920s, a brilliant scholar and classist named Milliam Parry made unique discovery. studying oral, epic poets in Balkans, discovered that Homer’s classic texts were obviously orally composed bear all of hallmarks such compositions. Parry, who passed away tragically at young age, was followed by host scholars argued much ancient Greek culture oral poetic nature shift towards written brough...

Background: Oral health is a key indicator of overall health, well-being and quality life. It covers wide range diseases conditions that include dental caries, periodontal disease, tooth loss, oral cancer, oro-dental trauma, normal birth defects such as cleft lip palate. Social culture affects socio-economic, lifestyle, gender culture. Methods: This study uses systematic review method on resear...