Current models of oncogenesis incorporate the contributions of chronic inflammation and aging to the patterns of tumor formation. These oncogenic pathways, involving leukocytes and fibroblasts, are not readily applicable to brain tumors (glioma), and other mechanisms must account for microenvironmental influences on central nervous system tumorigenesis. Previous studies from our laboratories ha...

A 32-year-old woman who died suddenly during pregnancy as a result of an adrenal phaeochromocytoma also suffered from von Recklinghausen's disease. 21 years earlier she had an optic nerve glioma successfully removed. The association between von Reckinghausen's disease and optic nerve glioma/phaeochromocytoma is well established. So far as is known, the present case is the first ever published w...

the case under consideration was a glioma of the optic nerve, one of the rarer tumors. microscopically it was diagnosed as a oligodendrocytoma. the patient, whose disease bage before the age of puberty, complain.ed of poor vision which in the course of five yars resulted in blindne