inconclusive because of small sample size. In the 1980s, the Optic Neuritis Treatment Trial was developed to evaluate corticosteroid treatment for optic neuritis. This multicenter randomized clinical trial, supported by the National Eye Institute, was designed to answer the following questions: (1) Does treatment with either oral prednisone or intravenous methylprednisolone followed by oral pre...

Background: Isolated relapsing optic neuropathy is a recurrent painful optic nerve inflammation without any sign of other demyelinating diseases such as multiple sclerosis (MS) or neuromyelitis optica (NMO) spectrum disorders, and the attacks are purely responsive to steroid therapy. Methods: Recurrent isolated optic neuritis (RION) was diagnosed in patients who presented with at least two diss...

BACKGROUND Numerous case reports have suggested a possible association between optic neuritis and receipt of several different vaccines. The most frequently identified vaccines associated with optic neuritis in the literature are influenza and hepatitis B, and a report describing 2 US military cases suggests an association with the currently used anthrax vaccine (anthrax vaccine adsorbed). OB...

The optic neuritis of systemic lupus erythematosus (S.L.E.) more frequently results in the persistence of a central scotoma or complete blindness after a single attack than demyelinating optic neuritis, although the initial clinical presentations may be identical. A significant number of patients, however, recover normal vision. Optic neuritis may be the presenting symptom of S.L.E. and as myel...

Parainfectious optic neuritis typically follows the onset of a viral or, less often, a bacterial infection by 1 to 3 weeks (37,434,435). It is more common in children than in adults and is thought to occur on an immunologic basis, producing demyelination of the optic nerve. The optic neuritis may be unilateral, but it is often bilateral. The optic discs may appear normal or swollen. Swelling of...

PURPOSE To report two cases of optic neuritis with onset less than 24 hours following measles-rubella (MR) vaccination. CASE REPORT Two teenage patients developed acute optic neuritis 6 to 7 hours after MR booster vaccination. The first patient demonstrated bilateral papillitis and severe visual loss but improved significantly with pulse intravenous steroid therapy with methylprednisolone 500...

Optic neuritis is a common presentation of demyelinating disorders such as multiple sclerosis. It typically presents with acute painful monocular vision loss, whereas chronic optic neuropathy can be caused by compressive lesions along the anterior visual pathway, genetic, toxic, or nutritional causes. We report an unusual presentation mimicking optic neuritis, which was subsequently diagnosed a...

In order to understand the vision of patients with long standing optic neuritis, contrast perception was analysed in some detail for three patients with uniocular anomalies. Contrast detection and contrast matching experiments each demonstrate anomalies in contrast processing for eyes with optic neuritis. In this regard, optic neuritis differs from all other visual anomalies so far investigated...

Demyelinating optic neuritis is the commonest cause of optic neuropathy in young adults. Retrobulbar optic neuritis is one of the frequent clinical forms of demyelinating optic neuritis. We report a case of a 28-year-old lady who presented with blurring of vision in the right eye for one month and pain on eye movement. Fundi examinations were normal. Initial suspicion was that of retrobulbar op...