The axons that make up the optic nerve originate from the retinal ganglion cells and extend from there to the lateral geniculate body. If cellular integrity is interrupted by disease anywhere along the course of an axon, degeneration occurs in both directions from the point of insult. Thus, axon frag­ ments between the site of injury and the lat­ eral geniculate body are separated from their nu...

a 15- year-old boy with history of bb gun injury to his left eye was referred to our center. his visual acuity was no light perception in the left eye. ocular findings were severe proptosis, conjunctival injection, and conjunctival vascular tortuosity. fundus examination revealed an extensive inferior chorioretinal scar compatible with chorioretinitis sclopetaria. a distinct bruit was detected ...

Optic disc pit and optic nerve coloboma are examples of congenital optic disc abnormalities. Although optic nerve coloboma can be inherited in an autosomal dominant fashion, no conclusive link has been found in the case of optic disc pit as an autosomal dominant disease. We describe two cases: a daughter with an optic disc pit complicated by maculopathy and her mother with a congenitally abnorm...

Abstract Optic nerve tuberculoma is a rare extra-pulmonary manifestation of mycobacterial infection. It usually associated with HIV infected patients. Due to its clinical polymorphism, the diagnosis and management disease either in immunocompetent patients immunocompromised ones remains challenging. Herein, we discuss case 32-year-old patient no history immunodeficiency admitted for multifocal ...

PURPOSE The aim of this study was to compare the asymmetrical light reflex of the control subjects and patients with optic nerve disease and to evaluate the relationships among the relative afferent pupillary defect (RAPD), visual acuity (VA), central critical fusion frequency (CFF), ganglion cell complex thickness (GCCT), and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) using ...

Inherited disorders of the optic nerve significantly impact vision in children and adults. The optic nerve disorders most commonly encountered clinically are glaucoma and primary optic neuropathy including Leber's hereditary optic neuropathy (LHON) and autosomal dominant or Kjer's optic atrophy. Current knowledge of the genetics of optic neuropathy and glaucoma makes it possible to test for mut...

PURPOSE Visual acuity (VA) disturbance other than field defect is important in evaluating patients with pituitary macroadenoma. The purpose of this study was to evaluate MR imaging appearances of optic nerves in patients with pituitary macroadenoma and to ascertain whether visual impairment was correlated with abnormality in optic nerve signal intensity. PATIENTS AND METHODS Twenty-seven pati...

Since its first description optic nerve hypoplasia has been identified with increasing frequency, and a range of associated problems have been described. The major neurological and endocrine associations are well established, but those factors that predispose to the development of optic nerve hypoplasia remain unclear. To understand the aetiology of these problems better, and to formulate a man...