The extent of cupping was measured from optic disc photographs of 300 patients with ocular hypertension and suspected or established chronic simple glaucoma, and their visual fields were recorded. The incidence of field defects increased as the vertical cup:disc ratio increased, a value of 0-70 for this ratio being a particularly useful guide to the presence or absence of field loss. There was ...

Optic disc cupping (ODC) is a classical feature of chronic simple glaucoma. In attempts to explain the pathogenesis of ODC, a very large volume of literature has accumulated since its discovery over I 20 years ago, but the mechanism is still far from clear. The presence of ODC with no rise in intraocular pressure (IOP), first described by von Graefe (I857), has further contributed to the confus...

Coloboma confined to the optic disc is a relatively rare condition (Steinberg, 1943), and has been described as unilateral in the majority of cases (Duke-Elder, I964; FranSois, I964). However, manifestation of the deformity may occur in the other eye (Hughes, 1947), and a number of bilateral cases have now been described. This paper records another bilateral case. A 35-year-old man was found to...

OBJECTIVE To compare the prevalence of structural and psychophysical abnormalities in normal eyes and eyes with glaucomatous optic neuropathy (GON) and normal standard automated perimetry (SAP). METHODS Complete examination, SAP, short-wavelength automated perimetry (SWAP), frequency doubling technology (FDT), scanning laser polarimetry (GDx-VCC), and optical coherence tomography (OCT) of the...

ALTHOUGH it has been recognized for very many years that various congenital anomalies of the optic nervehead occur, the influence of these on the progress of optic nerve disease seems to have been little studied. In particular, the influence of partial or complete inversion of the disc upon the nature of the cupping that occurs should a chronic glaucoma supervene has received little comment. Th...

PURPOSE The defining feature of glaucoma is excavation of the optic nerve head; however, the mechanism of this loss of tissue is not well understood. We recently discovered a copy number variation upstream of matrix metalloproteinase 19 (MMP19) in a large, autosomal dominant pedigree with a congenital malformation of the optic disc called cavitary optic disc anomaly (CODA). Patients with CODA h...

BACKGROUND To compare neuroretinal rim area measurements by confocal scanning laser tomography and planimetric evaluation of optic disc photographs. METHODS For 221 patients with primary and secondary open angle glaucoma, 72 subjects with ocular hypertension, and 139 normal subjects, the optic disc was morphometrically analysed by the confocal scanning laser tomograph HRT (Heidelberg retina t...

CASE REPORT A 34- year- old man affected by Klinefelter syndrome, with loss of vision in his left eye, ocular hypertension with increased cupping in both eyes, and optic disc pit with serous macular detachment in the left eye. Optical coherence tomography showed a macular detachment with a double-layer detachment, consisting of both an inner layer separation and an outer layer detachment. The o...