نتایج جستجو برای: opn gene

تعداد نتایج: 1142210  

Journal: :Circulation research 2002
Yuko Oyama Nobuhiro Akuzawa Ryozo Nagai Masahiko Kurabayashi

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily that acts as a key player in adipocyte differentiation, glucose metabolism, and macrophage differentiation. Osteopontin (OPN), a component of extracellular matrix, is elevated during neointimal formation in the vessel wall and is synthesized by macrophages in atherosclerotic plaques. In ...

Journal: :Brain : a journal of neurology 2006
Michael Schroeter Philipp Zickler David T Denhardt Hans-Peter Hartung Sebastian Jander

Inflammation aggravates brain injury caused by stroke and neurodegeneration. Osteopontin (OPN) is a cytokine-like glycoprotein that binds to various integrins and CD44 variants. OPN exerts proinflammatory effects in autoimmune conditions but also has cytoprotective properties and participates in wound healing. In this study, we addressed the role of OPN in ischaemic brain injury using OPN knock...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
D Panda G C Kundu B I Lee A Peri D Fohl I Chackalaparampil B B Mukherjee X D Li D C Mukherjee S Seides J Rosenberg K Stark A B Mukherjee

Angioplasty procedures are increasingly used to reestablish blood flow in blocked atherosclerotic coronary arteries. A serious complication of these procedures is reocclusion (restenosis), which occurs in 30-50% of patients. Migration of coronary artery smooth muscle cells (CASMCs) to the site of injury caused by angioplasty and subsequent proliferation are suggested mechanisms of reocclusion. ...

2013
Chao Zeng Shu-guang Gao Guang-hua Lei

INTRODUCTION A body of studies suggests the role of osteopontin (OPN) in onset and development of osteoarthritis (OA), however, the association between OPN polymorphisms and OA susceptibility as well as its clinical features has not been reported. METHODS A total of 750 patients with primary knee OA and 794 healthy volunteer were enrolled as controls. Both OA and control groups were interview...

2017
Fanglei Liu Chunxue Bai Zhongliang Guo

Osteopontin (OPN) is known to be overexpressed in numerous carcinomas. Although abundant OPN has been reported to be correlated with poor survival in non-small cell lung cancer (NSCLC) but their clinical and prognostic significance in SCLC remains unknown. In this study, RNA-sequencing was used to obtain gene expression data in SCLC tissue samples and OPN expression levels were then investigate...

2018
Chi-Shuan Fan Wei-Shone Chen Li-Li Chen Chia-Chi Chen Yu-Ting Hsu Kee Voon Chua Horng-Dar Wang Tze-Sing Huang

Osteopontin (OPN) is a multi-functional phospho-glycoprotein that can stimulate angiogenesis through acting on endothelial cells. As angiogenic sprouting involves endothelial-to-mesenchymal transition (EndoMT), we are intrigued to know whether OPN exerts an effect on EndoMT. Clinically, we indeed detected EndoMT-derived cells next to OPN-expressing cells in colorectal cancer tissues. Furthermor...

Journal: :The Journal of biological chemistry 2013
Yasuto Yamaguchi Zhifei Shao Shadi Sharif Xiao-Yan Du Timothy Myles Milton Merchant Griffith Harsh Michael Glantz Lawrence Recht John Morser Lawrence L K Leung

Osteopontin (OPN), which is highly expressed in malignant glioblastoma (GBM), possesses inflammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypeptidase B2 (CPB2) at a highly conserved cleavage site. Full-length OPN (OPN-FL) was elevated in cerebrospinal fluid (CSF) samples from all cancer patients compared with noncancer patients. However, thrombin-cleaved OPN (O...

2003
David T. Denhardt

The protein now known as OPN was first identified and characterized in two contexts: (a) in bone as a phosphorylated sialoglycoprotein (1); and (b) in cultures of transformed cells as transformation-related phosphoprotein (2). The rat cDNA encoding the bone protein was cloned from an osteosarcoma cell line and named OPN because of its ability to form a bridge between bone cells and bone matrix ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Jian-Su Shao Oscar L Sierra Richard Cohen Robert P Mecham Attila Kovacs James Wang Kathryn Distelhorst Abraham Behrmann Linda R Halstead Dwight A Towler

OBJECTIVE Calcification and fibrosis reduce vascular compliance in arteriosclerosis. To better understand the role of osteopontin (OPN), a multifunctional protein upregulated in diabetic arteries, we evaluated contributions of OPN in male low-density lipoprotein receptor (LDLR)-/- mice fed a high-fat diet. METHODS AND RESULTS OPN had no impact on high-fat diet-induced hyperglycemia, dyslipide...

2016
Qiu Yushi Zhimin Li Christina A. Von Roemeling Heike Doeppler Laura A. Marlow Betty Y.S. Kim Derek C. Radisky Peter Storz John A. Copland Han W. Tun

Osteopontin (OPN) is the most upregulated gene in primary central nervous system lymphoma (PCNSL) compared to non-CNS diffuse large B cell lymphoma (DLBCL). We show here that OPN is a key mediator of intracerebral tumor growth, invasion, and dissemination in CNS lymphoma, and that these effects depend upon activation of NF-κB. We further show that activation of NF-κB by OPN occurs through a uni...

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