Making a raft with oligomers pithelial cells differentially segregate proteins to their apical and basolateral surfaces. For some apical localization events, association of glycosylphosphatidylinositol (GPI)anchored proteins with detergent-resistant rafts is necessary but not sufficient. Now, on page 699, Paladino et al. show that the key for proper protein sorting may be the formation of high ...

This paper resolves two issues regarding diagnosis of tunneling opens: efficient screening and accurate localization. In the first part, a test pattern selection and sorting algorithm is presented. It is shown that the presented algorithm saves IDDQ(t) test time without impacting on its effectiveness. The second part of this paper presents a locating algorithm which combines both VLV and IDDQ(t...

Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler transcription factor retinoic acid receptor at previously unbound motifs. Thus, we demonstrate a new use for Cas9 in increasing surrounding chromati...

As circuit densities continue their increase, Automated Optical Inspection (AOI) augments traditional test methods for assuring quality of electronic assemblies. AOI is particularly helpful in assembly lines where both sides of a board are reflowed. This most modern style of construction leads to products of unprecedented density, but also brings us difficulties with in-circuit fixturing. The l...