Microspheres formulated from poly (D,L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres ...

Scanning Impedance Microscopy (SIM) is one of the novel scanning probe microscopy (SPM) techniques, which has been developed to taking image from sample surface, providing quantitative information with high lateral resolution on the interface capacitance, and investigating the local capacitance–voltage (C–V) behavior of the interface and AC transport properties. The SIM is an ordinary AFM equip...

OBJECTIVES To aid public health policy in preventing severe social exclusion (like homelessness) and promoting social inclusion (like labour market participation), we aimed to quantify (unmet) health needs of an expectedly vulnerable population on which little was known about: single male welfare recipients (SIM-welfare). One of the main policy questions was: is there need to promote access to ...

As part of its environmental remediation program at the Hanford Site, the U.S. Department of Energy needed a method to estimate ground contaminant source term inventories and uncertainties. To address this need, a stochastic model, the Hanford Soil Inventory Model (SIM), was created to provide inventories and uncertainties for 75 analytes to 377 different locations encompassing 57 years of oper...

The estrogen receptor (ER) functions as a dimer and is involved in several different biological functions. However ER dimeric proteins have not been identified by in situ methodologies. Structured illumination microscopy (SIM) has been recently developed, which enabled the localization of protein and protein interaction. Therefore, in this study, we firstly demonstrated that ERs formed both hom...

The design of modern complex embedded systems require a high level of abstraction of the design. The SimnML[1] is a specification language to model processors for such designs. Several software generation tools have been developed that take ISA specifications in Sim-nML as input. In this paper we present a tool Sim-HS that implements high level behavioral and structural synthesis of processors ...

Background Chest tube insertion is required for most cases of traumatic pneumothorax. However, this procedure entails risks of potentially life-threatening complications. A "surgical" approach is widely recommended to minimize these risks. Simulation-based education has previously been used in surgical chest tube insertion, but not been subjected to rigorous evaluation. Methods The primary ob...

BACKGROUND AND OBJECTIVES Evidence is conflicting with regards to the role of vitamin D in statin induced myalgia (SIM). Studies so far have assessed cross-sectional association and were limited by study sample selected predominantly from cardiology clinics. In this retrospective cohort study we assessed the association between vitamin D and SIM and attempted to establish a serum vitamin D cuto...

In this article we overview the ROme OpTimistic Simulator (ROOT-Sim), an open source C/MPI-based simulation package targeted at POSIX systems, which implements general-purpose parallel/distributed simulation environment relying on the optimistic (i.e. rollback based) synchronization paradigm. It offers a very simple programming model based on the classical notion of simulation-event handlers, t...